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BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer
PURPOSE: The primary aim of the present study was to analyze the association between high-risk clinicopathologic characteristics and the BRAFV600E mutation. METHODS: From March 2010 to September 2012, we performed analysis of the BRAF mutation (assessing V600E point mutation of BRAF gene, exon 15, o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196434/ https://www.ncbi.nlm.nih.gov/pubmed/25317411 http://dx.doi.org/10.4174/astr.2014.87.4.174 |
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author | Han, Sang-Ah Park, Won Seo Jang, Jae-Hoon Min, Sun-Young Ryu, Jung Kyu Song, Jeong-Yoon |
author_facet | Han, Sang-Ah Park, Won Seo Jang, Jae-Hoon Min, Sun-Young Ryu, Jung Kyu Song, Jeong-Yoon |
author_sort | Han, Sang-Ah |
collection | PubMed |
description | PURPOSE: The primary aim of the present study was to analyze the association between high-risk clinicopathologic characteristics and the BRAFV600E mutation. METHODS: From March 2010 to September 2012, we performed analysis of the BRAF mutation (assessing V600E point mutation of BRAF gene, exon 15, on chromosome 7q34 by real-time polymerase chain reaction kit) from 499 papillary thyroid carcinoma (PTC) patients who underwent thyroidectomy. We analyzed the relation between the mutation and known clinicopathologic risk factors of PTC. RESULTS: BRAF mutations were found in 353 of 499 patients (70.7%). On univariate analysis, BRAF mutations were more frequently detected in patients with central lymph node metastasis (78.5% vs. 66.7%, P = 0.007) and classic PTC type (71.3% vs. 16.7%, P = 0.011). Patients with one or more aggressive pathologic feature such as lymph node metastasis, multifocality, and extrathyroidal extension showed higher BRAF mutation rate (73.5% vs. 62.3%, P = 0.022). BRAF mutation group showed more aggressive pathologic features, which is considered as higher necessity of radioactive iodine ablation (relative risk, 1.617; P = 0.035). CONCLUSION: This study found that BRAF mutation is associated with classic PTC and central lymph node metastasis and higher necessity of radioactive iodine ablation. |
format | Online Article Text |
id | pubmed-4196434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-41964342014-10-14 BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer Han, Sang-Ah Park, Won Seo Jang, Jae-Hoon Min, Sun-Young Ryu, Jung Kyu Song, Jeong-Yoon Ann Surg Treat Res Original Article PURPOSE: The primary aim of the present study was to analyze the association between high-risk clinicopathologic characteristics and the BRAFV600E mutation. METHODS: From March 2010 to September 2012, we performed analysis of the BRAF mutation (assessing V600E point mutation of BRAF gene, exon 15, on chromosome 7q34 by real-time polymerase chain reaction kit) from 499 papillary thyroid carcinoma (PTC) patients who underwent thyroidectomy. We analyzed the relation between the mutation and known clinicopathologic risk factors of PTC. RESULTS: BRAF mutations were found in 353 of 499 patients (70.7%). On univariate analysis, BRAF mutations were more frequently detected in patients with central lymph node metastasis (78.5% vs. 66.7%, P = 0.007) and classic PTC type (71.3% vs. 16.7%, P = 0.011). Patients with one or more aggressive pathologic feature such as lymph node metastasis, multifocality, and extrathyroidal extension showed higher BRAF mutation rate (73.5% vs. 62.3%, P = 0.022). BRAF mutation group showed more aggressive pathologic features, which is considered as higher necessity of radioactive iodine ablation (relative risk, 1.617; P = 0.035). CONCLUSION: This study found that BRAF mutation is associated with classic PTC and central lymph node metastasis and higher necessity of radioactive iodine ablation. The Korean Surgical Society 2014-10 2014-09-25 /pmc/articles/PMC4196434/ /pubmed/25317411 http://dx.doi.org/10.4174/astr.2014.87.4.174 Text en Copyright © 2014, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/3.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Han, Sang-Ah Park, Won Seo Jang, Jae-Hoon Min, Sun-Young Ryu, Jung Kyu Song, Jeong-Yoon BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
title | BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
title_full | BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
title_fullStr | BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
title_full_unstemmed | BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
title_short | BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
title_sort | braf mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196434/ https://www.ncbi.nlm.nih.gov/pubmed/25317411 http://dx.doi.org/10.4174/astr.2014.87.4.174 |
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