Progranulin Protects against Amyloid β Deposition and Toxicity in Alzheimer’s Disease Mouse Models

Haploinsufficiency of progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD), and modulates an innate immune response in humans and mouse models. GRN polymorphism may be linked to late-onset Alzheimer’s disease (AD). However, PRGN’s role in AD pathogenesis is unknown....

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Detalles Bibliográficos
Autores principales: Minami, S. Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H., Elia, Lisa P., Ward, Michael E., Mucke, Lennart, Farese, Robert V., Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196723/
https://www.ncbi.nlm.nih.gov/pubmed/25261995
http://dx.doi.org/10.1038/nm.3672

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