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Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas

OBJECTIVE: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Yin Yang 1 (YY1) is a ubiquitous and multifunctional zinc-finger transcription factor that plays important biological functions in cell homeostasis and tumorigenesis. The purpose of this study was to inve...

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Autores principales: Luo, Judong, Jiang, Xin, Cao, LiLi, Dai, Kejun, Zhang, Shuyu, Ge, Xin, Zhou, Xifa, Lu, Xujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196789/
https://www.ncbi.nlm.nih.gov/pubmed/25328408
http://dx.doi.org/10.2147/OTT.S66667
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author Luo, Judong
Jiang, Xin
Cao, LiLi
Dai, Kejun
Zhang, Shuyu
Ge, Xin
Zhou, Xifa
Lu, Xujing
author_facet Luo, Judong
Jiang, Xin
Cao, LiLi
Dai, Kejun
Zhang, Shuyu
Ge, Xin
Zhou, Xifa
Lu, Xujing
author_sort Luo, Judong
collection PubMed
description OBJECTIVE: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Yin Yang 1 (YY1) is a ubiquitous and multifunctional zinc-finger transcription factor that plays important biological functions in cell homeostasis and tumorigenesis. The purpose of this study was to investigate the expression of YY1 in different ESCC tissues and the potential relationship with clinicopathological features. METHODS: One hundred and four ESCC tissues were collected in this study. The protein levels of YY1 were measured by immunohistochemistry. TE-1 cell invasion in vitro was assessed using the Transwell assay. RESULTS: There were no obvious differences between expression levels in patients over age 64 and those younger than 64, and no noticeable distinction was observed between males and females. However, the YY1 protein level was significantly higher in ESCC tissues with lymph node metastasis than those without lymph node metastasis (P=0.042). Furthermore, the expression of the YY1 protein was stronger in stage III–IV patients than in stage I–II patients (P=0.002), but the protein levels between different histological grades (well, moderate, or poor) showed no statistical significance. Similarly, there was no difference in YY1 expression in patients with or without lymphatic invasion. The Transwell assay revealed that the overexpression of YY1 promoted the invasion ability of TE-1 cells and the inhibition of YY1 could reverse this promotion. CONCLUSION: YY1 expression was associated with TNM stage and lymph node metastasis, suggesting that YY1 can influence human esophageal cancer progression and metastasis.
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spelling pubmed-41967892014-10-17 Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas Luo, Judong Jiang, Xin Cao, LiLi Dai, Kejun Zhang, Shuyu Ge, Xin Zhou, Xifa Lu, Xujing Onco Targets Ther Original Research OBJECTIVE: Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Yin Yang 1 (YY1) is a ubiquitous and multifunctional zinc-finger transcription factor that plays important biological functions in cell homeostasis and tumorigenesis. The purpose of this study was to investigate the expression of YY1 in different ESCC tissues and the potential relationship with clinicopathological features. METHODS: One hundred and four ESCC tissues were collected in this study. The protein levels of YY1 were measured by immunohistochemistry. TE-1 cell invasion in vitro was assessed using the Transwell assay. RESULTS: There were no obvious differences between expression levels in patients over age 64 and those younger than 64, and no noticeable distinction was observed between males and females. However, the YY1 protein level was significantly higher in ESCC tissues with lymph node metastasis than those without lymph node metastasis (P=0.042). Furthermore, the expression of the YY1 protein was stronger in stage III–IV patients than in stage I–II patients (P=0.002), but the protein levels between different histological grades (well, moderate, or poor) showed no statistical significance. Similarly, there was no difference in YY1 expression in patients with or without lymphatic invasion. The Transwell assay revealed that the overexpression of YY1 promoted the invasion ability of TE-1 cells and the inhibition of YY1 could reverse this promotion. CONCLUSION: YY1 expression was associated with TNM stage and lymph node metastasis, suggesting that YY1 can influence human esophageal cancer progression and metastasis. Dove Medical Press 2014-09-26 /pmc/articles/PMC4196789/ /pubmed/25328408 http://dx.doi.org/10.2147/OTT.S66667 Text en © 2014 Luo et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.
spellingShingle Original Research
Luo, Judong
Jiang, Xin
Cao, LiLi
Dai, Kejun
Zhang, Shuyu
Ge, Xin
Zhou, Xifa
Lu, Xujing
Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas
title Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas
title_full Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas
title_fullStr Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas
title_full_unstemmed Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas
title_short Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas
title_sort expression of yy1 correlates with progression and metastasis in esophageal squamous cell carcinomas
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196789/
https://www.ncbi.nlm.nih.gov/pubmed/25328408
http://dx.doi.org/10.2147/OTT.S66667
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