Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo

Platelet-derived growth factor (PDGF) and its receptors (PDGFR), including PDGFRα and PDGFRβ, play important roles in tumorigenesis, tumor progression, and the regulation of stromal cell function. Constitutive activation of PDGFR signaling, gene rearrangement, and activating mutations of PDGFR have...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Song, Liqiang, Ge, Hui, Jin, Pule, Jiang, Yifang, Hu, Wenxia, Geng, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196792/
https://www.ncbi.nlm.nih.gov/pubmed/25328409
http://dx.doi.org/10.2147/OTT.S68773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196792/
https://www.ncbi.nlm.nih.gov/pubmed/25328409
http://dx.doi.org/10.2147/OTT.S68773

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