Cargando…

Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo

Platelet-derived growth factor (PDGF) and its receptors (PDGFR), including PDGFRα and PDGFRβ, play important roles in tumorigenesis, tumor progression, and the regulation of stromal cell function. Constitutive activation of PDGFR signaling, gene rearrangement, and activating mutations of PDGFR have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ping, Song, Liqiang, Ge, Hui, Jin, Pule, Jiang, Yifang, Hu, Wenxia, Geng, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196792/ https://www.ncbi.nlm.nih.gov/pubmed/25328409 http://dx.doi.org/10.2147/OTT.S68773

Ejemplares similares

Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression
por: Berndsen, Robert H., et al.
Publicado: (2019)

Improved Recovery from Liver Fibrosis by Crenolanib
por: Reichert, Doreen, et al.
Publicado: (2021)

Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG
por: Tinkle, Christopher L, et al.
Publicado: (2021)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms
por: Zhang, Haijiao, et al.
Publicado: (2019)

Inhibition of proliferation and migration of luminal and claudin-low breast cancer cells by PDGFR inhibitors
por: Stalker, Leanne, et al.
Publicado: (2014)

Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia
por: Kampa-Schittenhelm, Kerstin Maria, et al.
Publicado: (2017)

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β
por: Ohishi, Jun, et al.
Publicado: (2013)

Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
por: Melaiu, Ombretta, et al.
Publicado: (2017)

Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ
por: O’Sullivan, Susannah, et al.
Publicado: (2016)

Dihydroartemisinin selectively inhibits PDGFRα-positive ovarian cancer growth and metastasis through inducing degradation of PDGFRα protein
por: Li, Xiaoguang, et al.
Publicado: (2017)

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations
por: Garz, Anne-Kathrin, et al.
Publicado: (2017)

TAS‐115 inhibits PDGFRα/AXL/FLT‐3 signaling and suppresses lung metastasis of osteosarcoma
por: Yasuda, Naohiro, et al.
Publicado: (2020)

miR-19a/b modulates lung cancer cells metastasis through suppression of MXD1 expression
por: Hu, Wenxia, et al.
Publicado: (2016)

Lycorine inhibits angiogenesis by docking to PDGFRα
por: Lv, Fei, et al.
Publicado: (2022)

GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo
por: ZHOU, XIANG, et al.
Publicado: (2015)

Gene expression-based screening for inhibitors of PDGFR signaling
por: Antipova, Alena A, et al.
Publicado: (2008)

Lineage Contribution of PDGFRα-Expressing Cells in the Developing Mouse Eye
por: Zhuo, Deyi, et al.
Publicado: (2021)

Plakoglobin Suppresses Epithelial Proliferation and Hair Growth in Vivo
por: Charpentier, Emmanuelle, et al.
Publicado: (2000)

GZD824 as a FLT3, FGFR1 and PDGFRα Inhibitor Against Leukemia In Vitro and In Vivo
por: Wang, Yuting, et al.
Publicado: (2020)

Gint4.T-Modified DNA Tetrahedrons Loaded with Doxorubicin Inhibits Glioma Cell Proliferation by Targeting PDGFRβ
por: Wang, Feng, et al.
Publicado: (2020)

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells
por: Wu, Erxi, et al.
Publicado: (2008)

LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling
por: Xiao, Qungen, et al.
Publicado: (2018)

LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling
por: Xiao, Qungen, et al.
Publicado: (2019)

LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling
por: Xiao, Qungen, et al.
Publicado: (2022)

Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma
por: Lee, Dae-Hee, et al.
Publicado: (2015)

Novel agent #2714 potently inhibits lung cancer growth by suppressing cell proliferation and by inducing apoptosis in vitro and in vivo
por: Lu, Wenjie, et al.
Publicado: (2019)

PDGFRα mediated survival of myofibroblasts inhibit satellite cell proliferation during aberrant regeneration of lacerated skeletal muscle
por: Thooyamani, Abinaya Sundari, et al.
Publicado: (2021)

Ezetimibe inhibits triple-negative breast cancer proliferation and promotes cell cycle arrest by targeting the PDGFR/AKT pathway
por: He, Qinyu, et al.
Publicado: (2023)

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
por: Tsioumpekou, Maria, et al.
Publicado: (2020)

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα
por: Fantauzzo, Katherine A., et al.
Publicado: (2016)

The Interaction of EphA4 With PDGFRβ Regulates Proliferation and Neuronal Differentiation of Neural Progenitor Cells in vitro and Promotes Neurogenesis in vivo
por: Chen, Qingfa, et al.
Publicado: (2020)

PDGFR‐β and kidney fibrosis
por: Ortiz, Alberto
Publicado: (2020)

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells
por: Kaulfuβ, Silke, et al.
Publicado: (2013)

Transactivation of PDGFRβ by dopamine D4 receptor does not require PDGFRβ dimerization
por: Chi, Sum Shing, et al.
Publicado: (2010)

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner
por: Wang, Fangqian, et al.
Publicado: (2023)

Additive effect by combination of Akt inhibitor, MK-2206, and PDGFR inhibitor, tyrphostin AG 1296, in suppressing anaplastic thyroid carcinoma cell viability and motility
por: Che, Huan-yong, et al.
Publicado: (2014)

MicroRNA-34A inhibits the growth, invasion and metastasis of gastric cancer by targeting PDGFR and MET expression
por: Peng, Yang, et al.
Publicado: (2014)

PDGFR-alpha inhibits melanoma growth via CXCL10/IP-10: a multi-omics approach
por: D'Arcangelo, Daniela, et al.
Publicado: (2016)

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression: Erratum
por: Tsioumpekou, Maria, et al.
Publicado: (2020)

miR-34a regulates mesangial cell proliferation via the PDGFR-β/Ras-MAPK signaling pathway
por: Chen, Dapeng, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ugh21p44t8ad2fnsu9jr8a1bl0