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Challenges in Developing a Validated Biomarker for Angiogenesis Inhibitors: The Motesanib Experience
PURPOSE: We sought to develop placental growth factor as a predictive pharmacodynamic biomarker for motesanib efficacy as first-line therapy in patients with advanced nonsquamous non–small-cell lung cancer. EXPERIMENTAL DESIGN: Placental growth factor was evaluated at baseline and study week 4 (afte...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196848/ https://www.ncbi.nlm.nih.gov/pubmed/25314641 http://dx.doi.org/10.1371/journal.pone.0108048 |