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A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes

OBJECTIVE: To improve the performance of glomerular filtration rate (GFR) estimating equation in Chinese type 2 diabetic patients by modification of the CKD-EPI equation. DESIGN AND PATIENTS: A total of 1196 subjects were enrolled. Measured GFR was calibrated to the dual plasma sample (99m)Tc-DTPA-G...

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Autores principales: Liu, Xun, Gan, Xiaoliang, Chen, Jinxia, Lv, Linsheng, Li, Ming, Lou, Tanqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196932/
https://www.ncbi.nlm.nih.gov/pubmed/25313918
http://dx.doi.org/10.1371/journal.pone.0109743
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author Liu, Xun
Gan, Xiaoliang
Chen, Jinxia
Lv, Linsheng
Li, Ming
Lou, Tanqi
author_facet Liu, Xun
Gan, Xiaoliang
Chen, Jinxia
Lv, Linsheng
Li, Ming
Lou, Tanqi
author_sort Liu, Xun
collection PubMed
description OBJECTIVE: To improve the performance of glomerular filtration rate (GFR) estimating equation in Chinese type 2 diabetic patients by modification of the CKD-EPI equation. DESIGN AND PATIENTS: A total of 1196 subjects were enrolled. Measured GFR was calibrated to the dual plasma sample (99m)Tc-DTPA-GFR. GFRs estimated by the re-expressed 4-variable MDRD equation, the CKD-EPI equation and the Asian modified CKD-EPI equation were compared in 351 diabetic/non-diabetic pairs. And a new modified CKD-EPI equation was reconstructed in a total of 589 type 2 diabetic patients. RESULTS: In terms of both precision and accuracy, GFR estimating equations all achieved better results in the non-diabetic cohort comparing with those in the type 2 diabetic cohort (30% accuracy, P≤0.01 for all comparisons). In the validation data set, the new modified equation showed less bias (median difference, 2.3 ml/min/1.73 m(2) for the new modified equation vs. ranged from −3.8 to −7.9 ml/min/1.73 m(2) for the other 3 equations [P<0.001 for all comparisons]), as was precision (IQR of the difference, 24.5 ml/min/1.73 m(2) vs. ranged from 27.3 to 30.7 ml/min/1.73 m(2)), leading to a greater accuracy (30% accuracy, 71.4% vs. 55.2% for the re-expressed 4 variable MDRD equation and 61.0% for the Asian modified CKD-EPI equation [P = 0.001 and P = 0.02]). CONCLUSION: A new modified CKD-EPI equation for type 2 diabetic patients was developed and validated. The new modified equation improves the performance of GFR estimation.
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spelling pubmed-41969322014-10-16 A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes Liu, Xun Gan, Xiaoliang Chen, Jinxia Lv, Linsheng Li, Ming Lou, Tanqi PLoS One Research Article OBJECTIVE: To improve the performance of glomerular filtration rate (GFR) estimating equation in Chinese type 2 diabetic patients by modification of the CKD-EPI equation. DESIGN AND PATIENTS: A total of 1196 subjects were enrolled. Measured GFR was calibrated to the dual plasma sample (99m)Tc-DTPA-GFR. GFRs estimated by the re-expressed 4-variable MDRD equation, the CKD-EPI equation and the Asian modified CKD-EPI equation were compared in 351 diabetic/non-diabetic pairs. And a new modified CKD-EPI equation was reconstructed in a total of 589 type 2 diabetic patients. RESULTS: In terms of both precision and accuracy, GFR estimating equations all achieved better results in the non-diabetic cohort comparing with those in the type 2 diabetic cohort (30% accuracy, P≤0.01 for all comparisons). In the validation data set, the new modified equation showed less bias (median difference, 2.3 ml/min/1.73 m(2) for the new modified equation vs. ranged from −3.8 to −7.9 ml/min/1.73 m(2) for the other 3 equations [P<0.001 for all comparisons]), as was precision (IQR of the difference, 24.5 ml/min/1.73 m(2) vs. ranged from 27.3 to 30.7 ml/min/1.73 m(2)), leading to a greater accuracy (30% accuracy, 71.4% vs. 55.2% for the re-expressed 4 variable MDRD equation and 61.0% for the Asian modified CKD-EPI equation [P = 0.001 and P = 0.02]). CONCLUSION: A new modified CKD-EPI equation for type 2 diabetic patients was developed and validated. The new modified equation improves the performance of GFR estimation. Public Library of Science 2014-10-14 /pmc/articles/PMC4196932/ /pubmed/25313918 http://dx.doi.org/10.1371/journal.pone.0109743 Text en © 2014 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Xun
Gan, Xiaoliang
Chen, Jinxia
Lv, Linsheng
Li, Ming
Lou, Tanqi
A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes
title A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes
title_full A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes
title_fullStr A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes
title_full_unstemmed A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes
title_short A New Modified CKD-EPI Equation for Chinese Patients with Type 2 Diabetes
title_sort new modified ckd-epi equation for chinese patients with type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196932/
https://www.ncbi.nlm.nih.gov/pubmed/25313918
http://dx.doi.org/10.1371/journal.pone.0109743
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