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Can multiple SNP testing in BRCA2 and BRCA1 female carriers be used to improve risk prediction models in conjunction with clinical assessment?

BACKGROUND: Several single nucleotide polymorphisms (SNPs) at different loci have been associated with breast cancer susceptibility, accounting for around 10% of the familial component. Recent studies have found direct associations between specific SNPs and breast cancer in BRCA1/2 mutation carriers...

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Detalles Bibliográficos
Autores principales:	Prosperi, Mattia CF, Ingham, Sarah L, Howell, Anthony, Lalloo, Fiona, Buchan, Iain E, Evans, Dafydd Gareth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197237/ https://www.ncbi.nlm.nih.gov/pubmed/25274085 http://dx.doi.org/10.1186/1472-6947-14-87

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