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AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Department of Journal of Biomedical Research
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197390/ https://www.ncbi.nlm.nih.gov/pubmed/25332711 http://dx.doi.org/10.7555/JBR.28.20140015 |
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author | Guo, Jia Chen, Xin Xi, Ruxing Chang, Yuwei Zhang, Xuanwei Zhang, Xiaozhi |
author_facet | Guo, Jia Chen, Xin Xi, Ruxing Chang, Yuwei Zhang, Xuanwei Zhang, Xiaozhi |
author_sort | Guo, Jia |
collection | PubMed |
description | Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P = 0.035) and PPP6c (r = 0.250, P = 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance. |
format | Online Article Text |
id | pubmed-4197390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Editorial Department of Journal of Biomedical Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-41973902014-10-20 AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues Guo, Jia Chen, Xin Xi, Ruxing Chang, Yuwei Zhang, Xuanwei Zhang, Xiaozhi J Biomed Res Research-Article Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P = 0.035) and PPP6c (r = 0.250, P = 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance. Editorial Department of Journal of Biomedical Research 2014-09 2014-08-12 /pmc/articles/PMC4197390/ /pubmed/25332711 http://dx.doi.org/10.7555/JBR.28.20140015 Text en 2014 the Journal of Biomedical Research. All rights reserved. |
spellingShingle | Research-Article Guo, Jia Chen, Xin Xi, Ruxing Chang, Yuwei Zhang, Xuanwei Zhang, Xiaozhi AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues |
title | AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues |
title_full | AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues |
title_fullStr | AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues |
title_full_unstemmed | AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues |
title_short | AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues |
title_sort | aeg-1 expression correlates with cd133 and ppp6c levels in human glioma tissues |
topic | Research-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197390/ https://www.ncbi.nlm.nih.gov/pubmed/25332711 http://dx.doi.org/10.7555/JBR.28.20140015 |
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