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AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues

Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the i...

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Autores principales: Guo, Jia, Chen, Xin, Xi, Ruxing, Chang, Yuwei, Zhang, Xuanwei, Zhang, Xiaozhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197390/
https://www.ncbi.nlm.nih.gov/pubmed/25332711
http://dx.doi.org/10.7555/JBR.28.20140015
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author Guo, Jia
Chen, Xin
Xi, Ruxing
Chang, Yuwei
Zhang, Xuanwei
Zhang, Xiaozhi
author_facet Guo, Jia
Chen, Xin
Xi, Ruxing
Chang, Yuwei
Zhang, Xuanwei
Zhang, Xiaozhi
author_sort Guo, Jia
collection PubMed
description Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P  =  0.035) and PPP6c (r =  0.250, P  =  0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
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spelling pubmed-41973902014-10-20 AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues Guo, Jia Chen, Xin Xi, Ruxing Chang, Yuwei Zhang, Xuanwei Zhang, Xiaozhi J Biomed Res Research-Article Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P  =  0.035) and PPP6c (r =  0.250, P  =  0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance. Editorial Department of Journal of Biomedical Research 2014-09 2014-08-12 /pmc/articles/PMC4197390/ /pubmed/25332711 http://dx.doi.org/10.7555/JBR.28.20140015 Text en 2014 the Journal of Biomedical Research. All rights reserved.
spellingShingle Research-Article
Guo, Jia
Chen, Xin
Xi, Ruxing
Chang, Yuwei
Zhang, Xuanwei
Zhang, Xiaozhi
AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
title AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
title_full AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
title_fullStr AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
title_full_unstemmed AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
title_short AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues
title_sort aeg-1 expression correlates with cd133 and ppp6c levels in human glioma tissues
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197390/
https://www.ncbi.nlm.nih.gov/pubmed/25332711
http://dx.doi.org/10.7555/JBR.28.20140015
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