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RSMD-repeat searcher and motif detector

The functionality of a gene or a protein depends on codon repeats occurring in it. As a consequence of their vitality in protein function and apparent involvement in causing diseases, an interest in these repeats has developed in recent years. The analysis of genomic and proteomic sequences to ident...

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Detalles Bibliográficos
Autores principales: Mani, Udayakumar, Mahaganapathy, Vaidhyanathan, Ravisankar, Sadhana, Ramakrishnan, Sai Mukund
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197393/
https://www.ncbi.nlm.nih.gov/pubmed/25332714
http://dx.doi.org/10.7555/JBR.28.20130065
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author Mani, Udayakumar
Mahaganapathy, Vaidhyanathan
Ravisankar, Sadhana
Ramakrishnan, Sai Mukund
author_facet Mani, Udayakumar
Mahaganapathy, Vaidhyanathan
Ravisankar, Sadhana
Ramakrishnan, Sai Mukund
author_sort Mani, Udayakumar
collection PubMed
description The functionality of a gene or a protein depends on codon repeats occurring in it. As a consequence of their vitality in protein function and apparent involvement in causing diseases, an interest in these repeats has developed in recent years. The analysis of genomic and proteomic sequences to identify such repeats requires some algorithmic support from informatics level. Here, we proposed an offline stand-alone toolkit Repeat Searcher and Motif Detector (RSMD), which uncovers and employs few novel approaches in identification of sequence repeats and motifs to understand their functionality in sequence level and their disease causing tendency. The tool offers various features such as identifying motifs, repeats and identification of disease causing repeats. RSMD was designed to provide an easily understandable graphical user interface (GUI), for the tool will be predominantly accessed by biologists and various researchers in all platforms of life science. GUI was developed using the scripting language Perl and its graphical module PerlTK. RSMD covers algorithmic foundations of computational biology by combining theory with practice.
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spelling pubmed-41973932014-10-20 RSMD-repeat searcher and motif detector Mani, Udayakumar Mahaganapathy, Vaidhyanathan Ravisankar, Sadhana Ramakrishnan, Sai Mukund J Biomed Res Research-Article The functionality of a gene or a protein depends on codon repeats occurring in it. As a consequence of their vitality in protein function and apparent involvement in causing diseases, an interest in these repeats has developed in recent years. The analysis of genomic and proteomic sequences to identify such repeats requires some algorithmic support from informatics level. Here, we proposed an offline stand-alone toolkit Repeat Searcher and Motif Detector (RSMD), which uncovers and employs few novel approaches in identification of sequence repeats and motifs to understand their functionality in sequence level and their disease causing tendency. The tool offers various features such as identifying motifs, repeats and identification of disease causing repeats. RSMD was designed to provide an easily understandable graphical user interface (GUI), for the tool will be predominantly accessed by biologists and various researchers in all platforms of life science. GUI was developed using the scripting language Perl and its graphical module PerlTK. RSMD covers algorithmic foundations of computational biology by combining theory with practice. Editorial Department of Journal of Biomedical Research 2014-09 2014-03-20 /pmc/articles/PMC4197393/ /pubmed/25332714 http://dx.doi.org/10.7555/JBR.28.20130065 Text en 2014 the Journal of Biomedical Research. All rights reserved.
spellingShingle Research-Article
Mani, Udayakumar
Mahaganapathy, Vaidhyanathan
Ravisankar, Sadhana
Ramakrishnan, Sai Mukund
RSMD-repeat searcher and motif detector
title RSMD-repeat searcher and motif detector
title_full RSMD-repeat searcher and motif detector
title_fullStr RSMD-repeat searcher and motif detector
title_full_unstemmed RSMD-repeat searcher and motif detector
title_short RSMD-repeat searcher and motif detector
title_sort rsmd-repeat searcher and motif detector
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197393/
https://www.ncbi.nlm.nih.gov/pubmed/25332714
http://dx.doi.org/10.7555/JBR.28.20130065
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