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RSMD-repeat searcher and motif detector
The functionality of a gene or a protein depends on codon repeats occurring in it. As a consequence of their vitality in protein function and apparent involvement in causing diseases, an interest in these repeats has developed in recent years. The analysis of genomic and proteomic sequences to ident...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Department of Journal of Biomedical Research
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197393/ https://www.ncbi.nlm.nih.gov/pubmed/25332714 http://dx.doi.org/10.7555/JBR.28.20130065 |
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author | Mani, Udayakumar Mahaganapathy, Vaidhyanathan Ravisankar, Sadhana Ramakrishnan, Sai Mukund |
author_facet | Mani, Udayakumar Mahaganapathy, Vaidhyanathan Ravisankar, Sadhana Ramakrishnan, Sai Mukund |
author_sort | Mani, Udayakumar |
collection | PubMed |
description | The functionality of a gene or a protein depends on codon repeats occurring in it. As a consequence of their vitality in protein function and apparent involvement in causing diseases, an interest in these repeats has developed in recent years. The analysis of genomic and proteomic sequences to identify such repeats requires some algorithmic support from informatics level. Here, we proposed an offline stand-alone toolkit Repeat Searcher and Motif Detector (RSMD), which uncovers and employs few novel approaches in identification of sequence repeats and motifs to understand their functionality in sequence level and their disease causing tendency. The tool offers various features such as identifying motifs, repeats and identification of disease causing repeats. RSMD was designed to provide an easily understandable graphical user interface (GUI), for the tool will be predominantly accessed by biologists and various researchers in all platforms of life science. GUI was developed using the scripting language Perl and its graphical module PerlTK. RSMD covers algorithmic foundations of computational biology by combining theory with practice. |
format | Online Article Text |
id | pubmed-4197393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Editorial Department of Journal of Biomedical Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-41973932014-10-20 RSMD-repeat searcher and motif detector Mani, Udayakumar Mahaganapathy, Vaidhyanathan Ravisankar, Sadhana Ramakrishnan, Sai Mukund J Biomed Res Research-Article The functionality of a gene or a protein depends on codon repeats occurring in it. As a consequence of their vitality in protein function and apparent involvement in causing diseases, an interest in these repeats has developed in recent years. The analysis of genomic and proteomic sequences to identify such repeats requires some algorithmic support from informatics level. Here, we proposed an offline stand-alone toolkit Repeat Searcher and Motif Detector (RSMD), which uncovers and employs few novel approaches in identification of sequence repeats and motifs to understand their functionality in sequence level and their disease causing tendency. The tool offers various features such as identifying motifs, repeats and identification of disease causing repeats. RSMD was designed to provide an easily understandable graphical user interface (GUI), for the tool will be predominantly accessed by biologists and various researchers in all platforms of life science. GUI was developed using the scripting language Perl and its graphical module PerlTK. RSMD covers algorithmic foundations of computational biology by combining theory with practice. Editorial Department of Journal of Biomedical Research 2014-09 2014-03-20 /pmc/articles/PMC4197393/ /pubmed/25332714 http://dx.doi.org/10.7555/JBR.28.20130065 Text en 2014 the Journal of Biomedical Research. All rights reserved. |
spellingShingle | Research-Article Mani, Udayakumar Mahaganapathy, Vaidhyanathan Ravisankar, Sadhana Ramakrishnan, Sai Mukund RSMD-repeat searcher and motif detector |
title | RSMD-repeat searcher and motif detector |
title_full | RSMD-repeat searcher and motif detector |
title_fullStr | RSMD-repeat searcher and motif detector |
title_full_unstemmed | RSMD-repeat searcher and motif detector |
title_short | RSMD-repeat searcher and motif detector |
title_sort | rsmd-repeat searcher and motif detector |
topic | Research-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197393/ https://www.ncbi.nlm.nih.gov/pubmed/25332714 http://dx.doi.org/10.7555/JBR.28.20130065 |
work_keys_str_mv | AT maniudayakumar rsmdrepeatsearcherandmotifdetector AT mahaganapathyvaidhyanathan rsmdrepeatsearcherandmotifdetector AT ravisankarsadhana rsmdrepeatsearcherandmotifdetector AT ramakrishnansaimukund rsmdrepeatsearcherandmotifdetector |