Co-activator independent differences in how the metaphase and anaphase APC/C recognise the same substrate

The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis, but how this is achieved is not well understood. We have addressed this question by deter...

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Detalles Bibliográficos
Autores principales: Matsusaka, Takahiro, Enquist-Newman, Maria, Morgan, David O., Pines, Jonathon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197439/
https://www.ncbi.nlm.nih.gov/pubmed/25217616
http://dx.doi.org/10.1242/bio.20149415

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