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Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors

Abstract Purpose: Treatment results evaluation (radical cystectomy and adjuvant chemo/radiotherapy) in patients with urothelial carcinoma, squamous differentiation carcinoma and pure squamous bladder carcinoma. Material and methods: The study included 361 patients with invasive bladder carcinoma tre...

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Autores principales: Gluck, G, Hortopan, M, Stănculeanu, D, Chiriță, M, Stoica, R, Sinescu, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197483/
https://www.ncbi.nlm.nih.gov/pubmed/25408727
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author Gluck, G
Hortopan, M
Stănculeanu, D
Chiriță, M
Stoica, R
Sinescu, I
author_facet Gluck, G
Hortopan, M
Stănculeanu, D
Chiriță, M
Stoica, R
Sinescu, I
author_sort Gluck, G
collection PubMed
description Abstract Purpose: Treatment results evaluation (radical cystectomy and adjuvant chemo/radiotherapy) in patients with urothelial carcinoma, squamous differentiation carcinoma and pure squamous bladder carcinoma. Material and methods: The study included 361 patients with invasive bladder carcinoma treated between 1990-2013. Histology showed 296 cases of urothelial carcinoma (82% - group A), 52 cases of urothelial divergent differentiation (squamous and urothelial carcinoma 14.4% - group B) and 13 cases of squamous cell carcinoma (3.6% - group C). All patients benefited from radical cystectomy. Adjuvant chemotherapy was undergone in 68 patients. Results: Group A - urothelial carcinoma - had a 44% rate of patients alive with a mean survival period of 73 months. About 56% of the patients died, the mean survival period being 4 years. Group B – urothelial carcinoma with squamous differentiation – had a mean survival period of 36 months (between 1-156 months). 17 patients (33%) are alive at 50 months postoperatively. Group C – squamous carcinoma – had a mean survival period of 9.4 months. Discussions: Locally advanced disease was diagnosed in 50% of the patients in group A, while in group B the rate was 84.6% and 70% in group C, respectively. Conclusions: Squamous pattern detected in the histopathological specimen represents a negative prognostic factor. It seems that the squamous component influences the outcome of the disease due to its biological characteristics in the evolution of squamous carcinoma, with advanced local stage disease at diagnosis – late onset of symptoms and lack of response to adjuvant treatment. Abbreviations: SCC = squamous cell carcinoma; MSK = Memorial Sloan Ketering
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spelling pubmed-41974832014-11-18 Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors Gluck, G Hortopan, M Stănculeanu, D Chiriță, M Stoica, R Sinescu, I J Med Life Case Presentation Abstract Purpose: Treatment results evaluation (radical cystectomy and adjuvant chemo/radiotherapy) in patients with urothelial carcinoma, squamous differentiation carcinoma and pure squamous bladder carcinoma. Material and methods: The study included 361 patients with invasive bladder carcinoma treated between 1990-2013. Histology showed 296 cases of urothelial carcinoma (82% - group A), 52 cases of urothelial divergent differentiation (squamous and urothelial carcinoma 14.4% - group B) and 13 cases of squamous cell carcinoma (3.6% - group C). All patients benefited from radical cystectomy. Adjuvant chemotherapy was undergone in 68 patients. Results: Group A - urothelial carcinoma - had a 44% rate of patients alive with a mean survival period of 73 months. About 56% of the patients died, the mean survival period being 4 years. Group B – urothelial carcinoma with squamous differentiation – had a mean survival period of 36 months (between 1-156 months). 17 patients (33%) are alive at 50 months postoperatively. Group C – squamous carcinoma – had a mean survival period of 9.4 months. Discussions: Locally advanced disease was diagnosed in 50% of the patients in group A, while in group B the rate was 84.6% and 70% in group C, respectively. Conclusions: Squamous pattern detected in the histopathological specimen represents a negative prognostic factor. It seems that the squamous component influences the outcome of the disease due to its biological characteristics in the evolution of squamous carcinoma, with advanced local stage disease at diagnosis – late onset of symptoms and lack of response to adjuvant treatment. Abbreviations: SCC = squamous cell carcinoma; MSK = Memorial Sloan Ketering Carol Davila University Press 2014-06-15 2014-06-25 /pmc/articles/PMC4197483/ /pubmed/25408727 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Presentation
Gluck, G
Hortopan, M
Stănculeanu, D
Chiriță, M
Stoica, R
Sinescu, I
Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
title Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
title_full Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
title_fullStr Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
title_full_unstemmed Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
title_short Comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
title_sort comparative study of conventional urothelial carcinoma, squamous differentiation carcinoma and pure squamous carcinoma in patients with invasive bladder tumors
topic Case Presentation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197483/
https://www.ncbi.nlm.nih.gov/pubmed/25408727
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