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Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury

Cardiac Ca(2+) cycling and signaling are closely associated with cardiac function. Changes in cellular Ca(2+) homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a ke...

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Autores principales: Choi, Eunhyun, Cha, Min-Ji, Hwang, Ki-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197635/
https://www.ncbi.nlm.nih.gov/pubmed/25216032
http://dx.doi.org/10.3390/cells3030899
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author Choi, Eunhyun
Cha, Min-Ji
Hwang, Ki-Chul
author_facet Choi, Eunhyun
Cha, Min-Ji
Hwang, Ki-Chul
author_sort Choi, Eunhyun
collection PubMed
description Cardiac Ca(2+) cycling and signaling are closely associated with cardiac function. Changes in cellular Ca(2+) homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca(2+)-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca(2+) homeostasis and signaling and miRNA, Ca(2+)-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca(2+) in cardiac function, as well as changes in Ca(2+) cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury.
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spelling pubmed-41976352014-10-16 Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury Choi, Eunhyun Cha, Min-Ji Hwang, Ki-Chul Cells Review Cardiac Ca(2+) cycling and signaling are closely associated with cardiac function. Changes in cellular Ca(2+) homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca(2+)-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca(2+) homeostasis and signaling and miRNA, Ca(2+)-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca(2+) in cardiac function, as well as changes in Ca(2+) cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury. MDPI 2014-09-11 /pmc/articles/PMC4197635/ /pubmed/25216032 http://dx.doi.org/10.3390/cells3030899 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Choi, Eunhyun
Cha, Min-Ji
Hwang, Ki-Chul
Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
title Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
title_full Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
title_fullStr Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
title_full_unstemmed Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
title_short Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
title_sort roles of calcium regulating micrornas in cardiac ischemia-reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197635/
https://www.ncbi.nlm.nih.gov/pubmed/25216032
http://dx.doi.org/10.3390/cells3030899
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