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Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
Cardiac Ca(2+) cycling and signaling are closely associated with cardiac function. Changes in cellular Ca(2+) homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a ke...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197635/ https://www.ncbi.nlm.nih.gov/pubmed/25216032 http://dx.doi.org/10.3390/cells3030899 |
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author | Choi, Eunhyun Cha, Min-Ji Hwang, Ki-Chul |
author_facet | Choi, Eunhyun Cha, Min-Ji Hwang, Ki-Chul |
author_sort | Choi, Eunhyun |
collection | PubMed |
description | Cardiac Ca(2+) cycling and signaling are closely associated with cardiac function. Changes in cellular Ca(2+) homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca(2+)-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca(2+) homeostasis and signaling and miRNA, Ca(2+)-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca(2+) in cardiac function, as well as changes in Ca(2+) cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury. |
format | Online Article Text |
id | pubmed-4197635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41976352014-10-16 Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury Choi, Eunhyun Cha, Min-Ji Hwang, Ki-Chul Cells Review Cardiac Ca(2+) cycling and signaling are closely associated with cardiac function. Changes in cellular Ca(2+) homeostasis may lead to aberrant cardiac rhythm and may play a critical role in the pathogenesis of cardiac diseases, due to their exacerbation of heart failure. MicroRNAs (miRNAs) play a key role in the regulation of gene expression at the post-transcriptional level and participate in regulating diverse biological processes. The emerging evidence indicates that the expression profiles of miRNAs vary among human diseases, including cardiovascular diseases. Cardiac Ca(2+)-handling and signaling proteins are also regulated by miRNAs. Given the relationship between cardiac Ca(2+) homeostasis and signaling and miRNA, Ca(2+)-related miRNAs may serve as therapeutic targets during the treatment of heart failure. In this review, we summarize the knowledge currently available regarding the role of Ca(2+) in cardiac function, as well as changes in Ca(2+) cycling and homeostasis and the handling of these processes by miRNAs during cardiac ischemia-reperfusion injury. MDPI 2014-09-11 /pmc/articles/PMC4197635/ /pubmed/25216032 http://dx.doi.org/10.3390/cells3030899 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Choi, Eunhyun Cha, Min-Ji Hwang, Ki-Chul Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury |
title | Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury |
title_full | Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury |
title_fullStr | Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury |
title_full_unstemmed | Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury |
title_short | Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury |
title_sort | roles of calcium regulating micrornas in cardiac ischemia-reperfusion injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197635/ https://www.ncbi.nlm.nih.gov/pubmed/25216032 http://dx.doi.org/10.3390/cells3030899 |
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