Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development

Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between β-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the β-catenin-dependent and β-catenin-independent...

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Autores principales: Cantù, Claudio, Zimmerli, Dario, Hausmann, George, Valenta, Tomas, Moor, Andreas, Aguet, Michel, Basler, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197948/
https://www.ncbi.nlm.nih.gov/pubmed/25184676
http://dx.doi.org/10.1101/gad.246140.114
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author Cantù, Claudio
Zimmerli, Dario
Hausmann, George
Valenta, Tomas
Moor, Andreas
Aguet, Michel
Basler, Konrad
author_facet Cantù, Claudio
Zimmerli, Dario
Hausmann, George
Valenta, Tomas
Moor, Andreas
Aguet, Michel
Basler, Konrad
author_sort Cantù, Claudio
collection PubMed
description Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between β-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the β-catenin-dependent and β-catenin-independent roles of Bcl9/9l and Pygo during mouse development. While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription.
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spelling pubmed-41979482015-03-01 Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development Cantù, Claudio Zimmerli, Dario Hausmann, George Valenta, Tomas Moor, Andreas Aguet, Michel Basler, Konrad Genes Dev Research Communication Bcl9 and Bcl9l (Bcl9/9l) encode Wnt signaling components that mediate the interaction between β-catenin and Pygopus (Pygo) via two evolutionarily conserved domains, HD1 and HD2, respectively. We generated mouse strains lacking these domains to probe the β-catenin-dependent and β-catenin-independent roles of Bcl9/9l and Pygo during mouse development. While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription. Cold Spring Harbor Laboratory Press 2014-09-01 /pmc/articles/PMC4197948/ /pubmed/25184676 http://dx.doi.org/10.1101/gad.246140.114 Text en © 2014 Cantù et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Communication
Cantù, Claudio
Zimmerli, Dario
Hausmann, George
Valenta, Tomas
Moor, Andreas
Aguet, Michel
Basler, Konrad
Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
title Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
title_full Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
title_fullStr Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
title_full_unstemmed Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
title_short Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
title_sort pax6-dependent, but β-catenin-independent, function of bcl9 proteins in mouse lens development
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197948/
https://www.ncbi.nlm.nih.gov/pubmed/25184676
http://dx.doi.org/10.1101/gad.246140.114
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