The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2

Cell type-specific conditional activation of oncogenic K-Ras is a powerful tool for investigating the cell of origin of adenocarcinomas in the mouse lung. Our previous studies showed that K-Ras activation with a CC10(Scgb1a1)-CreER driver leads to adenocarcinoma in a subset of alveolar type II cells...

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Detalles Bibliográficos
Autores principales: Xu, Xia, Huang, Lingling, Futtner, Christopher, Schwab, Brian, Rampersad, Rishi R., Lu, Yun, Sporn, Thomas A., Hogan, Brigid L.M., Onaitis, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197950/
https://www.ncbi.nlm.nih.gov/pubmed/25184679
http://dx.doi.org/10.1101/gad.243717.114

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