CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

One-year survival rates for newly diagnosed hepatocellular carcinoma (HCC) are <50%, and unresectable HCC carries a dismal prognosis owing to its aggressiveness and the undruggable nature of its main genetic drivers. By screening a custom library of shRNAs directed toward known drug targets in a...

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Detalles Bibliográficos
Autores principales: Huang, Chun-Hao, Lujambio, Amaia, Zuber, Johannes, Tschaharganeh, Darjus F., Doran, Michael G., Evans, Michael J., Kitzing, Thomas, Zhu, Nan, de Stanchina, Elisa, Sawyers, Charles L., Armstrong, Scott A., Lewis, Jason S., Sherr, Charles J., Lowe, Scott W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197965/
https://www.ncbi.nlm.nih.gov/pubmed/25128497
http://dx.doi.org/10.1101/gad.244368.114

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