Limiting the power of p53 through the ubiquitin proteasome pathway

The ubiquitin proteasome pathway is critical in restraining the activities of the p53 tumor suppressor. Numerous E3 and E4 ligases regulate p53 levels. Additionally, deubquitinating enzymes that modify p53 directly or indirectly also impact p53 function. When alterations of these proteins result in...

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Detalles Bibliográficos
Autores principales: Pant, Vinod, Lozano, Guillermina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197966/
https://www.ncbi.nlm.nih.gov/pubmed/25128494
http://dx.doi.org/10.1101/gad.247452.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197966/
https://www.ncbi.nlm.nih.gov/pubmed/25128494
http://dx.doi.org/10.1101/gad.247452.114

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