Understanding the Mechanism of Atovaquone Drug Resistance in Plasmodium falciparum Cytochrome b Mutation Y268S Using Computational Methods

The rapid appearance of resistant malarial parasites after introduction of atovaquone (ATQ) drug has prompted the search for new drugs as even single point mutations in the active site of Cytochrome b protein can rapidly render ATQ ineffective. The presence of Y268 mutations in the Cytochrome b (Cyt...

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Detalles Bibliográficos
Autores principales: Akhoon, Bashir A., Singh, Krishna P., Varshney, Megha, Gupta, Shishir K., Shukla, Yogeshwar, Gupta, Shailendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198183/
https://www.ncbi.nlm.nih.gov/pubmed/25334024
http://dx.doi.org/10.1371/journal.pone.0110041

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