Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain

BACKGROUND: Hypertrophic olivary degeneration (HOD) is a rare phenomenon, probably related to transsynaptic degeneration of the inferior olivary nucleus. It usually occurs as a response to primary injury of dento-rubro-olivary pathways. CASE REPORT: A young man developed Holmes' tremor 7 months...

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Autores principales: Menéndez, Djalma F. S., Cury, Rubens G., Barbosa, Egberto R., Teixeira, Manoel J., Fonoff, Erich T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2014
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198399/
https://www.ncbi.nlm.nih.gov/pubmed/25332842
http://dx.doi.org/10.7916/D8PG1PXT
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author Menéndez, Djalma F. S.
Cury, Rubens G.
Barbosa, Egberto R.
Teixeira, Manoel J.
Fonoff, Erich T.
author_facet Menéndez, Djalma F. S.
Cury, Rubens G.
Barbosa, Egberto R.
Teixeira, Manoel J.
Fonoff, Erich T.
author_sort Menéndez, Djalma F. S.
collection PubMed
description BACKGROUND: Hypertrophic olivary degeneration (HOD) is a rare phenomenon, probably related to transsynaptic degeneration of the inferior olivary nucleus. It usually occurs as a response to primary injury of dento-rubro-olivary pathways. CASE REPORT: A young man developed Holmes' tremor 7 months after a cavernous malformation bleed in the midbrain. Typical findings of HOD were observed in the magnetic resonance images: bilateral and asymmetric hypertrophy of the olivary nucleus with slight hypersignal in T2-weighted images. Because of the striking disability related to drug-resistant tremor, the patient underwent stereotactic thalamotomy (nucleus ventralis intermedius of the thalamus/zona incerta) with pronounced functional improvement over time. DISCUSSION: Disruption of circuits in the Guillain–Mollaret triangle classically results in palatal myoclonus, however midbrain (Holmes') tremor can also occur, as we now describe.
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spelling pubmed-41983992014-10-20 Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain Menéndez, Djalma F. S. Cury, Rubens G. Barbosa, Egberto R. Teixeira, Manoel J. Fonoff, Erich T. Tremor Other Hyperkinet Mov (N Y) Case Reports BACKGROUND: Hypertrophic olivary degeneration (HOD) is a rare phenomenon, probably related to transsynaptic degeneration of the inferior olivary nucleus. It usually occurs as a response to primary injury of dento-rubro-olivary pathways. CASE REPORT: A young man developed Holmes' tremor 7 months after a cavernous malformation bleed in the midbrain. Typical findings of HOD were observed in the magnetic resonance images: bilateral and asymmetric hypertrophy of the olivary nucleus with slight hypersignal in T2-weighted images. Because of the striking disability related to drug-resistant tremor, the patient underwent stereotactic thalamotomy (nucleus ventralis intermedius of the thalamus/zona incerta) with pronounced functional improvement over time. DISCUSSION: Disruption of circuits in the Guillain–Mollaret triangle classically results in palatal myoclonus, however midbrain (Holmes') tremor can also occur, as we now describe. Columbia University Libraries/Information Services 2014-10-08 /pmc/articles/PMC4198399/ /pubmed/25332842 http://dx.doi.org/10.7916/D8PG1PXT Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommerical–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed.
spellingShingle Case Reports
Menéndez, Djalma F. S.
Cury, Rubens G.
Barbosa, Egberto R.
Teixeira, Manoel J.
Fonoff, Erich T.
Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain
title Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain
title_full Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain
title_fullStr Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain
title_full_unstemmed Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain
title_short Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain
title_sort hypertrophic olivary degeneration and holmes' tremor secondary to bleeding of cavernous malformation in the midbrain
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198399/
https://www.ncbi.nlm.nih.gov/pubmed/25332842
http://dx.doi.org/10.7916/D8PG1PXT
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