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Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA
BACKGROUND: Mastitis is a major disease of dairy cattle occurring in response to environmental exposure to infective agents with a great economic impact on dairy industry. Somatic cell count (SCC) and its log transformation in somatic cell score (SCS) are traits that have been used as indirect measu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198737/ https://www.ncbi.nlm.nih.gov/pubmed/25288516 http://dx.doi.org/10.1186/s12863-014-0106-7 |
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author | Strillacci, Maria G Frigo, Erika Schiavini, Fausta Samoré, Antonia B Canavesi, Fabiola Vevey, Mario Cozzi, Maria C Soller, Morris Lipkin, Ehud Bagnato, Alessandro |
author_facet | Strillacci, Maria G Frigo, Erika Schiavini, Fausta Samoré, Antonia B Canavesi, Fabiola Vevey, Mario Cozzi, Maria C Soller, Morris Lipkin, Ehud Bagnato, Alessandro |
author_sort | Strillacci, Maria G |
collection | PubMed |
description | BACKGROUND: Mastitis is a major disease of dairy cattle occurring in response to environmental exposure to infective agents with a great economic impact on dairy industry. Somatic cell count (SCC) and its log transformation in somatic cell score (SCS) are traits that have been used as indirect measures of resistance to mastitis for decades in selective breeding. A selective DNA pooling (SDP) approach was applied to identify Quantitative Trait Loci (QTL) for SCS in Valdostana Red Pied cattle using the Illumina Bovine HD BeadChip. RESULTS: A total of 171 SNPs reached the genome-wide significance for association with SCS. Fifty-two SNPs were annotated within genes, some of those involved in the immune response to mastitis. On BTAs 1, 2, 3, 4, 9, 13, 15, 17, 21 and 22 the largest number of markers in association to the trait was found. These regions identified novel genomic regions related to mastitis (1-Mb SNP windows) and confirmed those already mapped. The largest number of significant SNPs exceeding the threshold for genome-wide significant signal was found on BTA 15, located at 50.43-51.63 Mb. CONCLUSIONS: The genomic regions identified in this study contribute to a better understanding of the genetic control of the mastitis immune response in cattle and may allow the inclusion of more detailed QTL information in selection programs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12863-014-0106-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4198737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41987372014-10-23 Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA Strillacci, Maria G Frigo, Erika Schiavini, Fausta Samoré, Antonia B Canavesi, Fabiola Vevey, Mario Cozzi, Maria C Soller, Morris Lipkin, Ehud Bagnato, Alessandro BMC Genet Research Article BACKGROUND: Mastitis is a major disease of dairy cattle occurring in response to environmental exposure to infective agents with a great economic impact on dairy industry. Somatic cell count (SCC) and its log transformation in somatic cell score (SCS) are traits that have been used as indirect measures of resistance to mastitis for decades in selective breeding. A selective DNA pooling (SDP) approach was applied to identify Quantitative Trait Loci (QTL) for SCS in Valdostana Red Pied cattle using the Illumina Bovine HD BeadChip. RESULTS: A total of 171 SNPs reached the genome-wide significance for association with SCS. Fifty-two SNPs were annotated within genes, some of those involved in the immune response to mastitis. On BTAs 1, 2, 3, 4, 9, 13, 15, 17, 21 and 22 the largest number of markers in association to the trait was found. These regions identified novel genomic regions related to mastitis (1-Mb SNP windows) and confirmed those already mapped. The largest number of significant SNPs exceeding the threshold for genome-wide significant signal was found on BTA 15, located at 50.43-51.63 Mb. CONCLUSIONS: The genomic regions identified in this study contribute to a better understanding of the genetic control of the mastitis immune response in cattle and may allow the inclusion of more detailed QTL information in selection programs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12863-014-0106-7) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-06 /pmc/articles/PMC4198737/ /pubmed/25288516 http://dx.doi.org/10.1186/s12863-014-0106-7 Text en © Strillacci et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Strillacci, Maria G Frigo, Erika Schiavini, Fausta Samoré, Antonia B Canavesi, Fabiola Vevey, Mario Cozzi, Maria C Soller, Morris Lipkin, Ehud Bagnato, Alessandro Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA |
title | Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA |
title_full | Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA |
title_fullStr | Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA |
title_full_unstemmed | Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA |
title_short | Genome-wide association study for somatic cell score in Valdostana Red Pied cattle breed using pooled DNA |
title_sort | genome-wide association study for somatic cell score in valdostana red pied cattle breed using pooled dna |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198737/ https://www.ncbi.nlm.nih.gov/pubmed/25288516 http://dx.doi.org/10.1186/s12863-014-0106-7 |
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