Cargando…
Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014
BACKGROUND: Combination antiretroviral therapy (cART) is the current strategy to prevent mother-to-child transmission (PMTCT) of HIV. Women initiated on cART should continue taking treatment life-long or stop after cessation of breastfeeding depending on their CD4 cell count or on their World Health...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198759/ https://www.ncbi.nlm.nih.gov/pubmed/25278351 http://dx.doi.org/10.1186/s13012-014-0139-3 |
_version_ | 1782339781035819008 |
---|---|
author | Claessens, Lore Voce, Anna Knight, Stephen Sartorius, Benn Coovadia, Ashraf |
author_facet | Claessens, Lore Voce, Anna Knight, Stephen Sartorius, Benn Coovadia, Ashraf |
author_sort | Claessens, Lore |
collection | PubMed |
description | BACKGROUND: Combination antiretroviral therapy (cART) is the current strategy to prevent mother-to-child transmission (PMTCT) of HIV. Women initiated on cART should continue taking treatment life-long or stop after cessation of breastfeeding depending on their CD4 cell count or on their World Health Organization (WHO) staging. Keeping people living with HIV on treatment is essential for the success of any antiretroviral therapy (ART) programme. There has been a rapid scale-up of cART in the PMTCT programme in South Africa. cART is supposed to be taken life-long or until cessation of breastfeeding, but premature or unmanaged discontinuation of cART postpartum is not unusual in South Africa and is confirmed by studies from around the world. Discontinuation of cART can lead to mother-to-child transmission (MTCT), drug resistance and poor maternal outcomes. The extent of this problem in the South African context however is unclear. This study aims to determine the prevalence of and identify risk factors associated with discontinuation of cART postpartum amongst women who were initiated on antiretroviral treatment during their index pregnancy. METHODS: An observational analytic cross-sectional study design will be conducted in six health facilities in a high prevalence district in KwaZulu-Natal, South Africa over a period of 3 months in 2014. An interviewer-administered questionnaire will be used to collect data from mothers who initiated cART during their index pregnancy. The prevalence of discontinuation of cART postpartum will be measured, and the association between those who discontinue cART postpartum and independent variables will be estimated using multivariable-adjusted prevalence odds ratios for discontinuation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13012-014-0139-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4198759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41987592014-10-17 Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 Claessens, Lore Voce, Anna Knight, Stephen Sartorius, Benn Coovadia, Ashraf Implement Sci Study Protocol BACKGROUND: Combination antiretroviral therapy (cART) is the current strategy to prevent mother-to-child transmission (PMTCT) of HIV. Women initiated on cART should continue taking treatment life-long or stop after cessation of breastfeeding depending on their CD4 cell count or on their World Health Organization (WHO) staging. Keeping people living with HIV on treatment is essential for the success of any antiretroviral therapy (ART) programme. There has been a rapid scale-up of cART in the PMTCT programme in South Africa. cART is supposed to be taken life-long or until cessation of breastfeeding, but premature or unmanaged discontinuation of cART postpartum is not unusual in South Africa and is confirmed by studies from around the world. Discontinuation of cART can lead to mother-to-child transmission (MTCT), drug resistance and poor maternal outcomes. The extent of this problem in the South African context however is unclear. This study aims to determine the prevalence of and identify risk factors associated with discontinuation of cART postpartum amongst women who were initiated on antiretroviral treatment during their index pregnancy. METHODS: An observational analytic cross-sectional study design will be conducted in six health facilities in a high prevalence district in KwaZulu-Natal, South Africa over a period of 3 months in 2014. An interviewer-administered questionnaire will be used to collect data from mothers who initiated cART during their index pregnancy. The prevalence of discontinuation of cART postpartum will be measured, and the association between those who discontinue cART postpartum and independent variables will be estimated using multivariable-adjusted prevalence odds ratios for discontinuation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13012-014-0139-3) contains supplementary material, which is available to authorized users. BioMed Central 2014-10-03 /pmc/articles/PMC4198759/ /pubmed/25278351 http://dx.doi.org/10.1186/s13012-014-0139-3 Text en © Claessens et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Study Protocol Claessens, Lore Voce, Anna Knight, Stephen Sartorius, Benn Coovadia, Ashraf Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 |
title | Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 |
title_full | Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 |
title_fullStr | Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 |
title_full_unstemmed | Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 |
title_short | Discontinuation of cART postpartum in a high prevalence district of South Africa in 2014 |
title_sort | discontinuation of cart postpartum in a high prevalence district of south africa in 2014 |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198759/ https://www.ncbi.nlm.nih.gov/pubmed/25278351 http://dx.doi.org/10.1186/s13012-014-0139-3 |
work_keys_str_mv | AT claessenslore discontinuationofcartpostpartuminahighprevalencedistrictofsouthafricain2014 AT voceanna discontinuationofcartpostpartuminahighprevalencedistrictofsouthafricain2014 AT knightstephen discontinuationofcartpostpartuminahighprevalencedistrictofsouthafricain2014 AT sartoriusbenn discontinuationofcartpostpartuminahighprevalencedistrictofsouthafricain2014 AT coovadiaashraf discontinuationofcartpostpartuminahighprevalencedistrictofsouthafricain2014 |