Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?

Children with AML become profoundly neutropenic while they undergo remission induction chemotherapy. It is unknown whether these children should be kept in the hospital while they are severely neutropenic to prevent life-threatening complications associated with neutropenia and reduce fatality. We a...

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Autores principales: Inoue, Susumu, Khan, Isra'a, Mushtaq, Rao, Carson, Dawn, Saah, Elna, Onwuzurike, Nkechi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198778/
https://www.ncbi.nlm.nih.gov/pubmed/25349742
http://dx.doi.org/10.1155/2014/592379
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author Inoue, Susumu
Khan, Isra'a
Mushtaq, Rao
Carson, Dawn
Saah, Elna
Onwuzurike, Nkechi
author_facet Inoue, Susumu
Khan, Isra'a
Mushtaq, Rao
Carson, Dawn
Saah, Elna
Onwuzurike, Nkechi
author_sort Inoue, Susumu
collection PubMed
description Children with AML become profoundly neutropenic while they undergo remission induction chemotherapy. It is unknown whether these children should be kept in the hospital while they are severely neutropenic to prevent life-threatening complications associated with neutropenia and reduce fatality. We at our institution routinely discharge patients after completing remission induction chemotherapy in the presence of profound neutropenia, unless it is clinically contraindicated. We reviewed all AML patients who were consecutively treated at our hospital from 1989 to 2011. Thirteen patients were electively discharged after completion of induction I chemotherapy. Of the 13, 4 died due to relapse or complications of stem cell transplants (not due to neutropenia related complications). Another eight are long term survivors. In this very small series, discharge from the hospital even though patients were severely neutropenic did not adversely affect the survival.
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spelling pubmed-41987782014-10-27 Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital? Inoue, Susumu Khan, Isra'a Mushtaq, Rao Carson, Dawn Saah, Elna Onwuzurike, Nkechi Leuk Res Treatment Clinical Study Children with AML become profoundly neutropenic while they undergo remission induction chemotherapy. It is unknown whether these children should be kept in the hospital while they are severely neutropenic to prevent life-threatening complications associated with neutropenia and reduce fatality. We at our institution routinely discharge patients after completing remission induction chemotherapy in the presence of profound neutropenia, unless it is clinically contraindicated. We reviewed all AML patients who were consecutively treated at our hospital from 1989 to 2011. Thirteen patients were electively discharged after completion of induction I chemotherapy. Of the 13, 4 died due to relapse or complications of stem cell transplants (not due to neutropenia related complications). Another eight are long term survivors. In this very small series, discharge from the hospital even though patients were severely neutropenic did not adversely affect the survival. Hindawi Publishing Corporation 2014 2014-09-29 /pmc/articles/PMC4198778/ /pubmed/25349742 http://dx.doi.org/10.1155/2014/592379 Text en Copyright © 2014 Susumu Inoue et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Inoue, Susumu
Khan, Isra'a
Mushtaq, Rao
Carson, Dawn
Saah, Elna
Onwuzurike, Nkechi
Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?
title Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?
title_full Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?
title_fullStr Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?
title_full_unstemmed Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?
title_short Postinduction Supportive Care of Pediatric Acute Myelocytic Leukemia: Should Patients be Kept in the Hospital?
title_sort postinduction supportive care of pediatric acute myelocytic leukemia: should patients be kept in the hospital?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198778/
https://www.ncbi.nlm.nih.gov/pubmed/25349742
http://dx.doi.org/10.1155/2014/592379
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