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Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy

Objective. To report our institutional seizure and neuropsychological outcomes for a series of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH) between 2004 and 2011. Methods. A retrospective study of patient...

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Autores principales: Mansouri, Alireza, Fallah, Aria, McAndrews, Mary Pat, Cohn, Melanie, Mayor, Diana, Andrade, Danielle, Carlen, Peter, del Campo, Jose M., Tai, Peter, Wennberg, Richard A., Valiante, Taufik A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198822/
https://www.ncbi.nlm.nih.gov/pubmed/25349728
http://dx.doi.org/10.1155/2014/306382
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author Mansouri, Alireza
Fallah, Aria
McAndrews, Mary Pat
Cohn, Melanie
Mayor, Diana
Andrade, Danielle
Carlen, Peter
del Campo, Jose M.
Tai, Peter
Wennberg, Richard A.
Valiante, Taufik A.
author_facet Mansouri, Alireza
Fallah, Aria
McAndrews, Mary Pat
Cohn, Melanie
Mayor, Diana
Andrade, Danielle
Carlen, Peter
del Campo, Jose M.
Tai, Peter
Wennberg, Richard A.
Valiante, Taufik A.
author_sort Mansouri, Alireza
collection PubMed
description Objective. To report our institutional seizure and neuropsychological outcomes for a series of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH) between 2004 and 2011. Methods. A retrospective study of patients with mTLE was conducted. Seizure outcome was reported using time-to-event analysis. Cognitive outcome was reported using the change principal in component factor scores, one each, for intellectual abilities, visuospatial memory, and verbal memory. The Boston Naming Test was used for naming assessment. Language dominant and nondominant resections were compared separately. Student's t-test was used to assess statistical significance. Results. Ninety-six patients (75 ATL, 21 SelAH) were included; fifty-four had complete neuropsychological follow-up. Median follow-up was 40.5 months. There was no statistically significant difference in seizure freedom or any of the neuropsychological outcomes, although there was a trend toward greater postoperative decline in naming in the dominant hemisphere group following ATL. Conclusion. Seizure and neuropsychological outcomes did not differ for the two surgical approaches which is similar to most prior studies. Given the theoretical possibility of SelAH sparing language function in patients with epilepsy secondary to mesial temporal sclerosis and the limited high-quality evidence creating equipoise, a multicenter randomized clinical trial is warranted.
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spelling pubmed-41988222014-10-27 Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy Mansouri, Alireza Fallah, Aria McAndrews, Mary Pat Cohn, Melanie Mayor, Diana Andrade, Danielle Carlen, Peter del Campo, Jose M. Tai, Peter Wennberg, Richard A. Valiante, Taufik A. Epilepsy Res Treat Clinical Study Objective. To report our institutional seizure and neuropsychological outcomes for a series of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH) between 2004 and 2011. Methods. A retrospective study of patients with mTLE was conducted. Seizure outcome was reported using time-to-event analysis. Cognitive outcome was reported using the change principal in component factor scores, one each, for intellectual abilities, visuospatial memory, and verbal memory. The Boston Naming Test was used for naming assessment. Language dominant and nondominant resections were compared separately. Student's t-test was used to assess statistical significance. Results. Ninety-six patients (75 ATL, 21 SelAH) were included; fifty-four had complete neuropsychological follow-up. Median follow-up was 40.5 months. There was no statistically significant difference in seizure freedom or any of the neuropsychological outcomes, although there was a trend toward greater postoperative decline in naming in the dominant hemisphere group following ATL. Conclusion. Seizure and neuropsychological outcomes did not differ for the two surgical approaches which is similar to most prior studies. Given the theoretical possibility of SelAH sparing language function in patients with epilepsy secondary to mesial temporal sclerosis and the limited high-quality evidence creating equipoise, a multicenter randomized clinical trial is warranted. Hindawi Publishing Corporation 2014 2014-10-01 /pmc/articles/PMC4198822/ /pubmed/25349728 http://dx.doi.org/10.1155/2014/306382 Text en Copyright © 2014 Alireza Mansouri et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Mansouri, Alireza
Fallah, Aria
McAndrews, Mary Pat
Cohn, Melanie
Mayor, Diana
Andrade, Danielle
Carlen, Peter
del Campo, Jose M.
Tai, Peter
Wennberg, Richard A.
Valiante, Taufik A.
Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy
title Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy
title_full Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy
title_fullStr Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy
title_full_unstemmed Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy
title_short Neurocognitive and Seizure Outcomes of Selective Amygdalohippocampectomy versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy
title_sort neurocognitive and seizure outcomes of selective amygdalohippocampectomy versus anterior temporal lobectomy for mesial temporal lobe epilepsy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198822/
https://www.ncbi.nlm.nih.gov/pubmed/25349728
http://dx.doi.org/10.1155/2014/306382
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