A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome

The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of...

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Autores principales: Sanders, Lucinda, Jayne, Sandrine, Kennedy, Ben, Miall, Fiona, Aukema, Sietse M., Siebert, Reiner, Wagner, Simon D., Dyer, Martin J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198823/
https://www.ncbi.nlm.nih.gov/pubmed/25349747
http://dx.doi.org/10.1155/2014/120714
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author Sanders, Lucinda
Jayne, Sandrine
Kennedy, Ben
Miall, Fiona
Aukema, Sietse M.
Siebert, Reiner
Wagner, Simon D.
Dyer, Martin J. S.
author_facet Sanders, Lucinda
Jayne, Sandrine
Kennedy, Ben
Miall, Fiona
Aukema, Sietse M.
Siebert, Reiner
Wagner, Simon D.
Dyer, Martin J. S.
author_sort Sanders, Lucinda
collection PubMed
description The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of high grade B-cell lymphoma, intermediate between DLBCL and BL, lacking CD10 expression in which the chromosomal translocation t(3;8)(q27;q24) was found to be the sole chromosomal abnormality. FISH analysis demonstrated juxtaposition of the BCL6 and MYC loci without obvious involvement of the IGH locus, suggesting constitutive MYC expression due to promoter substitution. The patient responded to intensive chemotherapy and remains in remission two years after finishing therapy.
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spelling pubmed-41988232014-10-27 A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome Sanders, Lucinda Jayne, Sandrine Kennedy, Ben Miall, Fiona Aukema, Sietse M. Siebert, Reiner Wagner, Simon D. Dyer, Martin J. S. Case Rep Hematol Case Report The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of high grade B-cell lymphoma, intermediate between DLBCL and BL, lacking CD10 expression in which the chromosomal translocation t(3;8)(q27;q24) was found to be the sole chromosomal abnormality. FISH analysis demonstrated juxtaposition of the BCL6 and MYC loci without obvious involvement of the IGH locus, suggesting constitutive MYC expression due to promoter substitution. The patient responded to intensive chemotherapy and remains in remission two years after finishing therapy. Hindawi Publishing Corporation 2014 2014-10-01 /pmc/articles/PMC4198823/ /pubmed/25349747 http://dx.doi.org/10.1155/2014/120714 Text en Copyright © 2014 Lucinda Sanders et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sanders, Lucinda
Jayne, Sandrine
Kennedy, Ben
Miall, Fiona
Aukema, Sietse M.
Siebert, Reiner
Wagner, Simon D.
Dyer, Martin J. S.
A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
title A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
title_full A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
title_fullStr A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
title_full_unstemmed A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
title_short A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome
title_sort double hit cd10-negative b-cell lymphoma with t(3;8)(q27;q24) leading to juxtaposition of the bcl6 and myc loci associated with good clinical outcome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198823/
https://www.ncbi.nlm.nih.gov/pubmed/25349747
http://dx.doi.org/10.1155/2014/120714
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