The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells

BACKGROUND: The small molecule NSC676914A was previously identified as an NF-κB inhibitor in TPA-stimulated HEK293 cells (Mol Can Ther 8:571-581, 2009). We hypothesized that this effect would also be seen in ovarian cancer cells, and serve as its mechanism of cytotoxicity. OVCAR3 and HEK293 cell lin...

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Detalles Bibliográficos
Autores principales: Sagher, Ethan, Hernandez, Lidia, Heywood, Callee, Pauly, Gary T, Young, Matthew R, Schneider, Joel, Colburn, Nancy H, Annunziata, Christina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198909/
https://www.ncbi.nlm.nih.gov/pubmed/25324692
http://dx.doi.org/10.1186/s12935-014-0075-y

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