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From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer

Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermedia...

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Detalles Bibliográficos
Autores principales: Bathe, Oliver F., Farshidfar, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198916/
https://www.ncbi.nlm.nih.gov/pubmed/25055199
http://dx.doi.org/10.3390/genes5030536
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author Bathe, Oliver F.
Farshidfar, Farshad
author_facet Bathe, Oliver F.
Farshidfar, Farshad
author_sort Bathe, Oliver F.
collection PubMed
description Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermediates in disease, provides a snapshot of the functional phenotype of colorectal cancer. Data, thus far, have characterized some of the metabolic perturbations that accompany colorectal cancer. However, further studies will be required to identify biologically meaningful metabolic subsets, including those corresponding to specific genetic aberrations. Moreover, further studies are necessary to distinguish changes due to tumor and the host response to tumor.
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spelling pubmed-41989162014-10-16 From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer Bathe, Oliver F. Farshidfar, Farshad Genes (Basel) Review Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermediates in disease, provides a snapshot of the functional phenotype of colorectal cancer. Data, thus far, have characterized some of the metabolic perturbations that accompany colorectal cancer. However, further studies will be required to identify biologically meaningful metabolic subsets, including those corresponding to specific genetic aberrations. Moreover, further studies are necessary to distinguish changes due to tumor and the host response to tumor. MDPI 2014-07-22 /pmc/articles/PMC4198916/ /pubmed/25055199 http://dx.doi.org/10.3390/genes5030536 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Bathe, Oliver F.
Farshidfar, Farshad
From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
title From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
title_full From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
title_fullStr From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
title_full_unstemmed From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
title_short From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
title_sort from genotype to functional phenotype: unraveling the metabolomic features of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198916/
https://www.ncbi.nlm.nih.gov/pubmed/25055199
http://dx.doi.org/10.3390/genes5030536
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