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From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer
Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermedia...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198916/ https://www.ncbi.nlm.nih.gov/pubmed/25055199 http://dx.doi.org/10.3390/genes5030536 |
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author | Bathe, Oliver F. Farshidfar, Farshad |
author_facet | Bathe, Oliver F. Farshidfar, Farshad |
author_sort | Bathe, Oliver F. |
collection | PubMed |
description | Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermediates in disease, provides a snapshot of the functional phenotype of colorectal cancer. Data, thus far, have characterized some of the metabolic perturbations that accompany colorectal cancer. However, further studies will be required to identify biologically meaningful metabolic subsets, including those corresponding to specific genetic aberrations. Moreover, further studies are necessary to distinguish changes due to tumor and the host response to tumor. |
format | Online Article Text |
id | pubmed-4198916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41989162014-10-16 From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer Bathe, Oliver F. Farshidfar, Farshad Genes (Basel) Review Much effort in recent years has been expended in defining the genomic and epigenetic alterations that characterize colorectal adenocarcinoma and its subtypes. However, little is known about the functional ramifications related to various subtypes. Metabolomics, the study of small molecule intermediates in disease, provides a snapshot of the functional phenotype of colorectal cancer. Data, thus far, have characterized some of the metabolic perturbations that accompany colorectal cancer. However, further studies will be required to identify biologically meaningful metabolic subsets, including those corresponding to specific genetic aberrations. Moreover, further studies are necessary to distinguish changes due to tumor and the host response to tumor. MDPI 2014-07-22 /pmc/articles/PMC4198916/ /pubmed/25055199 http://dx.doi.org/10.3390/genes5030536 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Bathe, Oliver F. Farshidfar, Farshad From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer |
title | From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer |
title_full | From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer |
title_fullStr | From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer |
title_full_unstemmed | From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer |
title_short | From Genotype to Functional Phenotype: Unraveling the Metabolomic Features of Colorectal Cancer |
title_sort | from genotype to functional phenotype: unraveling the metabolomic features of colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198916/ https://www.ncbi.nlm.nih.gov/pubmed/25055199 http://dx.doi.org/10.3390/genes5030536 |
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