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The Challenges of Genome Analysis in the Health Care Setting
Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s g...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198918/ https://www.ncbi.nlm.nih.gov/pubmed/25055201 http://dx.doi.org/10.3390/genes5030576 |
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author | Lucassen, Anneke Houlston, Richard S. |
author_facet | Lucassen, Anneke Houlston, Richard S. |
author_sort | Lucassen, Anneke |
collection | PubMed |
description | Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice. |
format | Online Article Text |
id | pubmed-4198918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41989182014-10-16 The Challenges of Genome Analysis in the Health Care Setting Lucassen, Anneke Houlston, Richard S. Genes (Basel) Review Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice. MDPI 2014-07-22 /pmc/articles/PMC4198918/ /pubmed/25055201 http://dx.doi.org/10.3390/genes5030576 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Lucassen, Anneke Houlston, Richard S. The Challenges of Genome Analysis in the Health Care Setting |
title | The Challenges of Genome Analysis in the Health Care Setting |
title_full | The Challenges of Genome Analysis in the Health Care Setting |
title_fullStr | The Challenges of Genome Analysis in the Health Care Setting |
title_full_unstemmed | The Challenges of Genome Analysis in the Health Care Setting |
title_short | The Challenges of Genome Analysis in the Health Care Setting |
title_sort | challenges of genome analysis in the health care setting |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198918/ https://www.ncbi.nlm.nih.gov/pubmed/25055201 http://dx.doi.org/10.3390/genes5030576 |
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