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The Challenges of Genome Analysis in the Health Care Setting

Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s g...

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Detalles Bibliográficos
Autores principales: Lucassen, Anneke, Houlston, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198918/
https://www.ncbi.nlm.nih.gov/pubmed/25055201
http://dx.doi.org/10.3390/genes5030576
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author Lucassen, Anneke
Houlston, Richard S.
author_facet Lucassen, Anneke
Houlston, Richard S.
author_sort Lucassen, Anneke
collection PubMed
description Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice.
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spelling pubmed-41989182014-10-16 The Challenges of Genome Analysis in the Health Care Setting Lucassen, Anneke Houlston, Richard S. Genes (Basel) Review Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians’ diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual’s genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice. MDPI 2014-07-22 /pmc/articles/PMC4198918/ /pubmed/25055201 http://dx.doi.org/10.3390/genes5030576 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Lucassen, Anneke
Houlston, Richard S.
The Challenges of Genome Analysis in the Health Care Setting
title The Challenges of Genome Analysis in the Health Care Setting
title_full The Challenges of Genome Analysis in the Health Care Setting
title_fullStr The Challenges of Genome Analysis in the Health Care Setting
title_full_unstemmed The Challenges of Genome Analysis in the Health Care Setting
title_short The Challenges of Genome Analysis in the Health Care Setting
title_sort challenges of genome analysis in the health care setting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198918/
https://www.ncbi.nlm.nih.gov/pubmed/25055201
http://dx.doi.org/10.3390/genes5030576
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