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Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C > T have a prognostic value in acute myeloid leukemia

BACKGROUND: The isocitrate dehydrogenase (IDH1/IDH2) genes are metabolic enzymes, which are frequently mutated in acute myeloid leukemia (AML). The enzymes acquire neomorphic enzymatic activity when they mutated. METHODS: We have investigated the frequency and outcome of the acquired IDH1/IDH2 mutat...

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Detalles Bibliográficos
Autores principales:	Willander, Kerstin, Falk, Ingrid Jakobsen, Chaireti, Roza, Paul, Esbjörn, Hermansson, Monica, Gréen, Henrik, Lotfi, Kourosh, Söderkvist, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198977/ https://www.ncbi.nlm.nih.gov/pubmed/25324972 http://dx.doi.org/10.1186/2050-7771-2-18

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