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Warped linear mixed models for the genetic analysis of transformed phenotypes
Linear mixed models (LMMs) are a powerful and established tool for studying genotype–phenotype relationships. A limitation of the LMM is that the model assumes Gaussian distributed residuals, a requirement that rarely holds in practice. Violations of this assumption can lead to false conclusions and...
Autores principales: | Fusi, Nicolo, Lippert, Christoph, Lawrence, Neil D., Stegle, Oliver |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199105/ https://www.ncbi.nlm.nih.gov/pubmed/25234577 http://dx.doi.org/10.1038/ncomms5890 |
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