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Crystal structure of a common GPCR-binding interface for G protein and arrestin

G-protein-coupled receptors (GPCRs) transmit extracellular signals to activate intracellular heterotrimeric G proteins (Gαβγ) and arrestins. For G protein signalling, the Gα C-terminus (GαCT) binds to a cytoplasmic crevice of the receptor that opens upon activation. A consensus motif is shared among...

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Detalles Bibliográficos
Autores principales:	Szczepek, Michal, Beyrière, Florent, Hofmann, Klaus Peter, Elgeti, Matthias, Kazmin, Roman, Rose, Alexander, Bartl, Franz J., von Stetten, David, Heck, Martin, Sommer, Martha E., Hildebrand, Peter W., Scheerer, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199108/ https://www.ncbi.nlm.nih.gov/pubmed/25205354 http://dx.doi.org/10.1038/ncomms5801

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