Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice

DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral glucose administration at advanced age increases health and lifespan of telomere dysfunctional mice. The study reveals that energy consumption increases in telomere dysfunctional cells resulting in enhanced gluco...

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Detalles Bibliográficos
Autores principales: Missios, Pavlos, Zhou, Yuan, Guachalla, Luis Miguel, von Figura, Guido, Wegner, Andre, Chakkarappan, Sundaram Reddy, Binz, Tina, Gompf, Anne, Hartleben, Götz, Burkhalter, Martin D., Wulff, Veronika, Günes, Cagatay, Sattler, Rui Wang, Song, Zhangfa, Illig, Thomas, Klaus, Susanne, Böhm, Bernhard O., Wenz, Tina, Hiller, Karsten, Rudolph, K. Lenhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199114/
https://www.ncbi.nlm.nih.gov/pubmed/25233189
http://dx.doi.org/10.1038/ncomms5924

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