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Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis

Objectives. To empirically determine a categorization of people who inject drug (PWIDs) recently infected with hepatitis C virus (HCV), in order to identify profiles most likely associated with early HCV treatment uptake. Methods. The study population was composed of HIV-negative PWIDs with a docume...

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Autores principales: Bamvita, Jean-Marie, Roy, Elise, Zang, Geng, Jutras-Aswad, Didier, Artenie, Andreea Adelina, Levesque, Annie, Bruneau, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199115/
https://www.ncbi.nlm.nih.gov/pubmed/25349730
http://dx.doi.org/10.1155/2014/631481
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author Bamvita, Jean-Marie
Roy, Elise
Zang, Geng
Jutras-Aswad, Didier
Artenie, Andreea Adelina
Levesque, Annie
Bruneau, Julie
author_facet Bamvita, Jean-Marie
Roy, Elise
Zang, Geng
Jutras-Aswad, Didier
Artenie, Andreea Adelina
Levesque, Annie
Bruneau, Julie
author_sort Bamvita, Jean-Marie
collection PubMed
description Objectives. To empirically determine a categorization of people who inject drug (PWIDs) recently infected with hepatitis C virus (HCV), in order to identify profiles most likely associated with early HCV treatment uptake. Methods. The study population was composed of HIV-negative PWIDs with a documented recent HCV infection. Eligibility criteria included being 18 years old or over, and having injected drugs in the previous 6 months preceding the estimated date of HCV exposure. Participant classification was carried out using a TwoStep cluster analysis. Results. From September 2007 to December 2011, 76 participants were included in the study. 60 participants were eligible for HCV treatment. Twenty-one participants initiated HCV treatment. The cluster analysis yielded 4 classes: class 1: Lukewarm health seekers dismissing HCV treatment offer; class 2: multisubstance users willing to shake off the hell; class 3: PWIDs unlinked to health service use; class 4: health seeker PWIDs willing to reverse the fate. Conclusion. Profiles generated by our analysis suggest that prior health care utilization, a key element for treatment uptake, differs between older and younger PWIDs. Such profiles could inform the development of targeted strategies to improve health outcomes and reduce HCV infection among PWIDs.
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spelling pubmed-41991152014-10-27 Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis Bamvita, Jean-Marie Roy, Elise Zang, Geng Jutras-Aswad, Didier Artenie, Andreea Adelina Levesque, Annie Bruneau, Julie Hepat Res Treat Research Article Objectives. To empirically determine a categorization of people who inject drug (PWIDs) recently infected with hepatitis C virus (HCV), in order to identify profiles most likely associated with early HCV treatment uptake. Methods. The study population was composed of HIV-negative PWIDs with a documented recent HCV infection. Eligibility criteria included being 18 years old or over, and having injected drugs in the previous 6 months preceding the estimated date of HCV exposure. Participant classification was carried out using a TwoStep cluster analysis. Results. From September 2007 to December 2011, 76 participants were included in the study. 60 participants were eligible for HCV treatment. Twenty-one participants initiated HCV treatment. The cluster analysis yielded 4 classes: class 1: Lukewarm health seekers dismissing HCV treatment offer; class 2: multisubstance users willing to shake off the hell; class 3: PWIDs unlinked to health service use; class 4: health seeker PWIDs willing to reverse the fate. Conclusion. Profiles generated by our analysis suggest that prior health care utilization, a key element for treatment uptake, differs between older and younger PWIDs. Such profiles could inform the development of targeted strategies to improve health outcomes and reduce HCV infection among PWIDs. Hindawi Publishing Corporation 2014 2014-10-01 /pmc/articles/PMC4199115/ /pubmed/25349730 http://dx.doi.org/10.1155/2014/631481 Text en Copyright © 2014 Jean-Marie Bamvita et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bamvita, Jean-Marie
Roy, Elise
Zang, Geng
Jutras-Aswad, Didier
Artenie, Andreea Adelina
Levesque, Annie
Bruneau, Julie
Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis
title Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis
title_full Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis
title_fullStr Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis
title_full_unstemmed Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis
title_short Portraying Persons Who Inject Drugs Recently Infected with Hepatitis C Accessing Antiviral Treatment: A Cluster Analysis
title_sort portraying persons who inject drugs recently infected with hepatitis c accessing antiviral treatment: a cluster analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199115/
https://www.ncbi.nlm.nih.gov/pubmed/25349730
http://dx.doi.org/10.1155/2014/631481
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