C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

Mutation is associated with developmental and hereditary disorders, aging, and cancer. While we understand some mutational processes operative in human disease, most remain mysterious. We used Caenorhabditis elegans whole-genome sequencing to model mutational signatures, analyzing 183 worm populatio...

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Detalles Bibliográficos
Autores principales: Meier, Bettina, Cooke, Susanna L., Weiss, Joerg, Bailly, Aymeric P., Alexandrov, Ludmil B., Marshall, John, Raine, Keiran, Maddison, Mark, Anderson, Elizabeth, Stratton, Michael R., Gartner, Anton, Campbell, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199376/
https://www.ncbi.nlm.nih.gov/pubmed/25030888
http://dx.doi.org/10.1101/gr.175547.114

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