A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21(WAF1/CIP1)) Degradation

Exposure to ultraviolet (UV) radiation from sunlight accounts for 90% of the symptoms of premature skin aging and skin cancer. The tumor suppressor serine-threonine kinase LKB1 is mutated in Peutz-Jeghers syndrome and in a spectrum of epithelial cancers whose etiology suggests a cooperation with env...

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Detalles Bibliográficos
Autores principales: Esteve-Puig, Rosaura, Gil, Rosa, González-Sánchez, Elena, Bech-Serra, Joan Josep, Grueso, Judit, Hernández-Losa, Javier, Moliné, Teresa, Canals, Francesc, Ferrer, Berta, Cortés, Javier, Bastian, Boris, Ramón y Cajal, Santiago, Martín-Caballero, Juan, Flores, Juana Maria, Vivancos, Ana, García-Patos, Vicenç, Recio, Juan Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199501/
https://www.ncbi.nlm.nih.gov/pubmed/25329316
http://dx.doi.org/10.1371/journal.pgen.1004721

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