Early Double-Negative Thymocyte Export in Trypanosoma cruzi Infection Is Restricted by Sphingosine Receptors and Associated with Human Chagas Disease

The protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the thymic microenvironmental and lymphoid compartments. Acute infection results in severe atrophy of the organ and early release of immature thymocytes into the periphery. To date, the pathophysiological...

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Detalles Bibliográficos
Autores principales: Lepletier, Ailin, de Almeida, Liliane, Santos, Leonardo, da Silva Sampaio, Luzia, Paredes, Bruno, González, Florencia Belén, Freire-de-Lima, Célio Geraldo, Beloscar, Juan, Bottasso, Oscar, Einicker-Lamas, Marcelo, Pérez, Ana Rosa, Savino, Wilson, Morrot, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199546/
https://www.ncbi.nlm.nih.gov/pubmed/25330249
http://dx.doi.org/10.1371/journal.pntd.0003203

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