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Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China

BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease that is caused by a novel bunyavirus, referred to as SFTS virus. During January 2011 to December 2011 we conducted a case-control study in Henan, Hubei and Shandong Provinces of China to determine the risk factors...

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Autores principales: Ding, Fan, Guan, Xu-Hua, Kang, Kai, Ding, Shu-Jun, Huang, Li-Yong, Xing, Xue-Sen, Sha, Sha, Liu, Li, Wang, Xian-Jun, Zhang, Xiao-Mei, You, Ai-Guo, Du, Yan-Hua, Zhou, Hang, Vong, Sirenda, Zhang, Xiao-Dong, Feng, Zi-Jian, Yang, Wei-Zhong, Li, Qun, Yin, Wen-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199554/
https://www.ncbi.nlm.nih.gov/pubmed/25330383
http://dx.doi.org/10.1371/journal.pntd.0003267
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author Ding, Fan
Guan, Xu-Hua
Kang, Kai
Ding, Shu-Jun
Huang, Li-Yong
Xing, Xue-Sen
Sha, Sha
Liu, Li
Wang, Xian-Jun
Zhang, Xiao-Mei
You, Ai-Guo
Du, Yan-Hua
Zhou, Hang
Vong, Sirenda
Zhang, Xiao-Dong
Feng, Zi-Jian
Yang, Wei-Zhong
Li, Qun
Yin, Wen-Wu
author_facet Ding, Fan
Guan, Xu-Hua
Kang, Kai
Ding, Shu-Jun
Huang, Li-Yong
Xing, Xue-Sen
Sha, Sha
Liu, Li
Wang, Xian-Jun
Zhang, Xiao-Mei
You, Ai-Guo
Du, Yan-Hua
Zhou, Hang
Vong, Sirenda
Zhang, Xiao-Dong
Feng, Zi-Jian
Yang, Wei-Zhong
Li, Qun
Yin, Wen-Wu
author_sort Ding, Fan
collection PubMed
description BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease that is caused by a novel bunyavirus, referred to as SFTS virus. During January 2011 to December 2011 we conducted a case-control study in Henan, Hubei and Shandong Provinces of China to determine the risk factors for SFTS. METHODS: Case-patients were identified in hospitals and reported to provincial Centers for Disease Control and Prevention while being notified electronically to the National Surveillance System. Controls were randomly selected from a pool of patients admitted to the same hospital ward within one week of the inclusion of the cases. They were matched by age (+/−5 years) and gender. RESULTS: A total of 422 patients participated in the study including 134 cases and 288 matched controls. The median age of the cases was 58.8 years, ranging from 47.6 to 70.1 years; 54.5% were male. No differences in demographics were observed between cases and controls; however, farmers were frequent and more common among cases (88.8%) than controls (58.7%). In multivariate analysis, the odds for SFTS was 2.4∼4.5 fold higher with patients who reported tick bites or presence of tick in the living area. Other independent risk factors included cat or cattle ownership and reported presence of weeds and shrubs in the working environment. CONCLUSIONS: Our findings support the hypothesis that ticks are important vectors of SFTS virus. Further investigations are warranted to understand the detailed modes of transmission of SFTS virus while vector management, education on tick bites prevention and personal hygiene management should be implemented for high-risk groups in high incidence areas.
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spelling pubmed-41995542014-10-21 Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China Ding, Fan Guan, Xu-Hua Kang, Kai Ding, Shu-Jun Huang, Li-Yong Xing, Xue-Sen Sha, Sha Liu, Li Wang, Xian-Jun Zhang, Xiao-Mei You, Ai-Guo Du, Yan-Hua Zhou, Hang Vong, Sirenda Zhang, Xiao-Dong Feng, Zi-Jian Yang, Wei-Zhong Li, Qun Yin, Wen-Wu PLoS Negl Trop Dis Research Article BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease that is caused by a novel bunyavirus, referred to as SFTS virus. During January 2011 to December 2011 we conducted a case-control study in Henan, Hubei and Shandong Provinces of China to determine the risk factors for SFTS. METHODS: Case-patients were identified in hospitals and reported to provincial Centers for Disease Control and Prevention while being notified electronically to the National Surveillance System. Controls were randomly selected from a pool of patients admitted to the same hospital ward within one week of the inclusion of the cases. They were matched by age (+/−5 years) and gender. RESULTS: A total of 422 patients participated in the study including 134 cases and 288 matched controls. The median age of the cases was 58.8 years, ranging from 47.6 to 70.1 years; 54.5% were male. No differences in demographics were observed between cases and controls; however, farmers were frequent and more common among cases (88.8%) than controls (58.7%). In multivariate analysis, the odds for SFTS was 2.4∼4.5 fold higher with patients who reported tick bites or presence of tick in the living area. Other independent risk factors included cat or cattle ownership and reported presence of weeds and shrubs in the working environment. CONCLUSIONS: Our findings support the hypothesis that ticks are important vectors of SFTS virus. Further investigations are warranted to understand the detailed modes of transmission of SFTS virus while vector management, education on tick bites prevention and personal hygiene management should be implemented for high-risk groups in high incidence areas. Public Library of Science 2014-10-16 /pmc/articles/PMC4199554/ /pubmed/25330383 http://dx.doi.org/10.1371/journal.pntd.0003267 Text en © 2014 Ding et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ding, Fan
Guan, Xu-Hua
Kang, Kai
Ding, Shu-Jun
Huang, Li-Yong
Xing, Xue-Sen
Sha, Sha
Liu, Li
Wang, Xian-Jun
Zhang, Xiao-Mei
You, Ai-Guo
Du, Yan-Hua
Zhou, Hang
Vong, Sirenda
Zhang, Xiao-Dong
Feng, Zi-Jian
Yang, Wei-Zhong
Li, Qun
Yin, Wen-Wu
Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China
title Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China
title_full Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China
title_fullStr Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China
title_full_unstemmed Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China
title_short Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome, China
title_sort risk factors for bunyavirus-associated severe fever with thrombocytopenia syndrome, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199554/
https://www.ncbi.nlm.nih.gov/pubmed/25330383
http://dx.doi.org/10.1371/journal.pntd.0003267
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