Cigarette Smoke Extract Induces a Phenotypic Shift in Epithelial Cells; Involvement of HIF1α in Mesenchymal Transition

In COPD, matrix remodeling contributes to airflow limitation. Recent evidence suggests that next to fibroblasts, the process of epithelial-mesenchymal transition can contribute to matrix remodeling. CSE has been shown to induce EMT in lung epithelial cells, but the signaling mechanisms involved are...

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Detalles Bibliográficos
Autores principales: Eurlings, Irene M. J., Reynaert, Niki L., van den Beucken, Twan, Gosker, Harry R., de Theije, C. C., Verhamme, Fien M., Bracke, Ken R., Wouters, Emiel F. M., Dentener, Mieke A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199572/
https://www.ncbi.nlm.nih.gov/pubmed/25329389
http://dx.doi.org/10.1371/journal.pone.0107757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199572/
https://www.ncbi.nlm.nih.gov/pubmed/25329389
http://dx.doi.org/10.1371/journal.pone.0107757

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