Myxoma Virus Expressing a Fusion Protein of Interleukin-15 (IL15) and IL15 Receptor Alpha Has Enhanced Antitumor Activity

Myxoma virus, a rabbit poxvirus, can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit-specific pathogen, and is thought to be safe as a therapeutic agent in all non-rabbit hosts tested including mice and humans. Interleukin-15 (IL15) is an immuno-modulatory cyt...

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Detalles Bibliográficos
Autores principales: Tosic, Vesna, Thomas, Diana L., Kranz, David M., Liu, Jia, McFadden, Grant, Shisler, Joanna L., MacNeill, Amy L., Roy, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199602/
https://www.ncbi.nlm.nih.gov/pubmed/25329832
http://dx.doi.org/10.1371/journal.pone.0109801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199602/
https://www.ncbi.nlm.nih.gov/pubmed/25329832
http://dx.doi.org/10.1371/journal.pone.0109801

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