Nuclear Expression of the Deubiquitinase CYLD Is Associated with Improved Survival in Human Hepatocellular Carcinoma

BACKGROUND & AIMS: The deubiquitinase CYLD removes (K-63)-linked polyubiquitin chains from proteins involved in NF-κB, Wnt/ß-catenin and Bcl-3 signaling. Reduced CYLD expression has been reported in different tumor entities, including hepatocellular carcinoma (HCC). Furthermore, loss of CYLD has...

Descripción completa

Detalles Bibliográficos
Autores principales: Welte, Stefan, Urbanik, Toni, Elßner, Christin, Kautz, Nicole, Koehler, Bruno Christian, Waldburger, Nina, Bermejo, Justo Lorenzo, Pinna, Federico, Weiss, Karl-Heinz, Schemmer, Peter, Jaeger, Dirk, Longerich, Thomas, Breuhahn, Kai, Schulze-Bergkamen, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199737/
https://www.ncbi.nlm.nih.gov/pubmed/25329885
http://dx.doi.org/10.1371/journal.pone.0110591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199737/
https://www.ncbi.nlm.nih.gov/pubmed/25329885
http://dx.doi.org/10.1371/journal.pone.0110591

Ejemplares similares