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Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo
Plasma membrane organization is under the control of cytoskeletal networks and endocytic mechanisms, and a growing literature is showing how closely these influences are interconnected. Here, we review how plasma membranes are formed around individual nuclei of the syncytial Drosophila embryo. Speci...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199814/ https://www.ncbi.nlm.nih.gov/pubmed/24874871 http://dx.doi.org/10.4161/bioa.28949 |
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author | Lee, Donghoon M Harris, Tony JC |
author_facet | Lee, Donghoon M Harris, Tony JC |
author_sort | Lee, Donghoon M |
collection | PubMed |
description | Plasma membrane organization is under the control of cytoskeletal networks and endocytic mechanisms, and a growing literature is showing how closely these influences are interconnected. Here, we review how plasma membranes are formed around individual nuclei of the syncytial Drosophila embryo. Specifically, we outline the pathways that promote and maintain the growth of pseudocleavage and cellularization furrows, as well as specific pathways that keep furrow growth in check. This system has become important for studies of actin regulators, such as Rho1, Diaphanous, non-muscle myosin II and Arp2/3, and endocytic regulators, such as a cytohesin Arf-GEF (Steppke), clathrin, Amphiphysin and dynamin. More generally, it provides a model for understanding how cytoskeletal-endocytic cross-talk regulates the assembly of a cell. |
format | Online Article Text |
id | pubmed-4199814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-41998142015-03-04 Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo Lee, Donghoon M Harris, Tony JC Bioarchitecture Commentary Plasma membrane organization is under the control of cytoskeletal networks and endocytic mechanisms, and a growing literature is showing how closely these influences are interconnected. Here, we review how plasma membranes are formed around individual nuclei of the syncytial Drosophila embryo. Specifically, we outline the pathways that promote and maintain the growth of pseudocleavage and cellularization furrows, as well as specific pathways that keep furrow growth in check. This system has become important for studies of actin regulators, such as Rho1, Diaphanous, non-muscle myosin II and Arp2/3, and endocytic regulators, such as a cytohesin Arf-GEF (Steppke), clathrin, Amphiphysin and dynamin. More generally, it provides a model for understanding how cytoskeletal-endocytic cross-talk regulates the assembly of a cell. Landes Bioscience 2014 2014-04-23 /pmc/articles/PMC4199814/ /pubmed/24874871 http://dx.doi.org/10.4161/bioa.28949 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Commentary Lee, Donghoon M Harris, Tony JC Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo |
title | Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo |
title_full | Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo |
title_fullStr | Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo |
title_full_unstemmed | Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo |
title_short | Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo |
title_sort | coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early drosophila embryo |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199814/ https://www.ncbi.nlm.nih.gov/pubmed/24874871 http://dx.doi.org/10.4161/bioa.28949 |
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