Identification of 33 candidate oncogenes by screening for base-specific mutations

BACKGROUND: Genes with recurrent codon-specific somatic mutations are likely drivers of tumorigenesis and potential therapeutic targets. Hypermutable cancers may represent a sensitive system for generation and selection of oncogenic mutations. METHODS: We utilised exome-sequencing data on 25 sporadi...

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Detalles Bibliográficos
Autores principales: Tuupanen, S, Hänninen, U A, Kondelin, J, von Nandelstadh, P, Cajuso, T, Gylfe, A E, Katainen, R, Tanskanen, T, Ristolainen, H, Böhm, J, Mecklin, J-P, Järvinen, H, Renkonen-Sinisalo, L, Andersen, C L, Taipale, M, Taipale, J, Vahteristo, P, Lehti, K, Pitkänen, E, Aaltonen, L A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200084/
https://www.ncbi.nlm.nih.gov/pubmed/25117815
http://dx.doi.org/10.1038/bjc.2014.429

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