Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome

The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenua...

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Autores principales: Yang, Dongmei, Alam, Zohaib, Cui, Xiaohong, Chen, Michael, Sherrod, Carly J., McVoy, Michael A., Schleiss, Mark R., Dittmer, Dirk P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200145/
https://www.ncbi.nlm.nih.gov/pubmed/25323707
http://dx.doi.org/10.1128/genomeA.00928-14
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author Yang, Dongmei
Alam, Zohaib
Cui, Xiaohong
Chen, Michael
Sherrod, Carly J.
McVoy, Michael A.
Schleiss, Mark R.
Dittmer, Dirk P.
author_facet Yang, Dongmei
Alam, Zohaib
Cui, Xiaohong
Chen, Michael
Sherrod, Carly J.
McVoy, Michael A.
Schleiss, Mark R.
Dittmer, Dirk P.
author_sort Yang, Dongmei
collection PubMed
description The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.
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spelling pubmed-42001452014-10-24 Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome Yang, Dongmei Alam, Zohaib Cui, Xiaohong Chen, Michael Sherrod, Carly J. McVoy, Michael A. Schleiss, Mark R. Dittmer, Dirk P. Genome Announc Viruses The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130. American Society for Microbiology 2014-10-16 /pmc/articles/PMC4200145/ /pubmed/25323707 http://dx.doi.org/10.1128/genomeA.00928-14 Text en Copyright © 2014 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Viruses
Yang, Dongmei
Alam, Zohaib
Cui, Xiaohong
Chen, Michael
Sherrod, Carly J.
McVoy, Michael A.
Schleiss, Mark R.
Dittmer, Dirk P.
Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome
title Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome
title_full Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome
title_fullStr Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome
title_full_unstemmed Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome
title_short Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome
title_sort complete genome sequence of cell culture-attenuated guinea pig cytomegalovirus cloned as an infectious bacterial artificial chromosome
topic Viruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200145/
https://www.ncbi.nlm.nih.gov/pubmed/25323707
http://dx.doi.org/10.1128/genomeA.00928-14
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