CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia

The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large s...

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Detalles Bibliográficos
Autores principales: Cui, Yajuan, Li, Bing, Gale, Robert Peter, Jiang, Qian, Xu, Zefeng, Qin, Tiejun, Zhang, Peihong, Zhang, Yue, Xiao, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200198/
https://www.ncbi.nlm.nih.gov/pubmed/25316523
http://dx.doi.org/10.1186/s13045-014-0077-1
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author Cui, Yajuan
Li, Bing
Gale, Robert Peter
Jiang, Qian
Xu, Zefeng
Qin, Tiejun
Zhang, Peihong
Zhang, Yue
Xiao, Zhijian
author_facet Cui, Yajuan
Li, Bing
Gale, Robert Peter
Jiang, Qian
Xu, Zefeng
Qin, Tiejun
Zhang, Peihong
Zhang, Yue
Xiao, Zhijian
author_sort Cui, Yajuan
collection PubMed
description The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large studies of this issue. We sequenced these genes in 14 patients who met the WHO-criteria of CNL. 8 subjects had CSF3R(T618I), 6 SETBP1 mutations and 1 a CALR mutation. Our data suggest mutation analysis of CSF3R, SETBP1 and CALR should be included in the diagnostic criteria for CNL. These data may also have therapy implications.
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spelling pubmed-42001982014-10-18 CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia Cui, Yajuan Li, Bing Gale, Robert Peter Jiang, Qian Xu, Zefeng Qin, Tiejun Zhang, Peihong Zhang, Yue Xiao, Zhijian J Hematol Oncol Letter to the Editor The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). However, because CNL is rare, there are few large studies of this issue. We sequenced these genes in 14 patients who met the WHO-criteria of CNL. 8 subjects had CSF3R(T618I), 6 SETBP1 mutations and 1 a CALR mutation. Our data suggest mutation analysis of CSF3R, SETBP1 and CALR should be included in the diagnostic criteria for CNL. These data may also have therapy implications. BioMed Central 2014-10-15 /pmc/articles/PMC4200198/ /pubmed/25316523 http://dx.doi.org/10.1186/s13045-014-0077-1 Text en © Cui et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Cui, Yajuan
Li, Bing
Gale, Robert Peter
Jiang, Qian
Xu, Zefeng
Qin, Tiejun
Zhang, Peihong
Zhang, Yue
Xiao, Zhijian
CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
title CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
title_full CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
title_fullStr CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
title_full_unstemmed CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
title_short CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia
title_sort csf3r, setbp1 and calr mutations in chronic neutrophilic leukemia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200198/
https://www.ncbi.nlm.nih.gov/pubmed/25316523
http://dx.doi.org/10.1186/s13045-014-0077-1
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