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Coagulation in sepsis: all bugs bite equally

Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis...

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Detalles Bibliográficos
Autores principales: Levi, Marcel, van der Poll, Tom
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420035/
https://www.ncbi.nlm.nih.gov/pubmed/15025767
http://dx.doi.org/10.1186/cc2816
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author Levi, Marcel
van der Poll, Tom
author_facet Levi, Marcel
van der Poll, Tom
author_sort Levi, Marcel
collection PubMed
description Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis. There is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulation disorder.
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spelling pubmed-4200352004-06-04 Coagulation in sepsis: all bugs bite equally Levi, Marcel van der Poll, Tom Crit Care Commentary Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis. There is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulation disorder. BioMed Central 2004 2004-02-10 /pmc/articles/PMC420035/ /pubmed/15025767 http://dx.doi.org/10.1186/cc2816 Text en Copyright © BioMed Central Ltd
spellingShingle Commentary
Levi, Marcel
van der Poll, Tom
Coagulation in sepsis: all bugs bite equally
title Coagulation in sepsis: all bugs bite equally
title_full Coagulation in sepsis: all bugs bite equally
title_fullStr Coagulation in sepsis: all bugs bite equally
title_full_unstemmed Coagulation in sepsis: all bugs bite equally
title_short Coagulation in sepsis: all bugs bite equally
title_sort coagulation in sepsis: all bugs bite equally
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420035/
https://www.ncbi.nlm.nih.gov/pubmed/15025767
http://dx.doi.org/10.1186/cc2816
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