Cargando…
Coagulation in sepsis: all bugs bite equally
Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2004
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420035/ https://www.ncbi.nlm.nih.gov/pubmed/15025767 http://dx.doi.org/10.1186/cc2816 |
_version_ | 1782121456321167360 |
---|---|
author | Levi, Marcel van der Poll, Tom |
author_facet | Levi, Marcel van der Poll, Tom |
author_sort | Levi, Marcel |
collection | PubMed |
description | Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis. There is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulation disorder. |
format | Text |
id | pubmed-420035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-4200352004-06-04 Coagulation in sepsis: all bugs bite equally Levi, Marcel van der Poll, Tom Crit Care Commentary Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III clinical trial of recombinant activated protein C in patients with severe sepsis confirm this notion and demonstrate that the vast majority of patients with severe sepsis have increased markers for systemic coagulation activation, decreased physiological anticoagulant proteins and depressed fibrinolysis. There is no correlation between the type of microorganism that has caused the infection and the presence or severity of the coagulation disorder. BioMed Central 2004 2004-02-10 /pmc/articles/PMC420035/ /pubmed/15025767 http://dx.doi.org/10.1186/cc2816 Text en Copyright © BioMed Central Ltd |
spellingShingle | Commentary Levi, Marcel van der Poll, Tom Coagulation in sepsis: all bugs bite equally |
title | Coagulation in sepsis: all bugs bite equally |
title_full | Coagulation in sepsis: all bugs bite equally |
title_fullStr | Coagulation in sepsis: all bugs bite equally |
title_full_unstemmed | Coagulation in sepsis: all bugs bite equally |
title_short | Coagulation in sepsis: all bugs bite equally |
title_sort | coagulation in sepsis: all bugs bite equally |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC420035/ https://www.ncbi.nlm.nih.gov/pubmed/15025767 http://dx.doi.org/10.1186/cc2816 |
work_keys_str_mv | AT levimarcel coagulationinsepsisallbugsbiteequally AT vanderpolltom coagulationinsepsisallbugsbiteequally |