Profiling individual human red blood cells using common-path diffraction optical tomography

Due to its strong correlation with the pathophysiology of many diseases, information about human red blood cells (RBCs) has a crucial function in hematology. Therefore, measuring and understanding the morphological, chemical, and mechanical properties of individual RBCs is a key to understanding the...

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Autores principales: Kim, Youngchan, Shim, Hyoeun, Kim, Kyoohyun, Park, HyunJoo, Jang, Seongsoo, Park, YongKeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200412/
https://www.ncbi.nlm.nih.gov/pubmed/25322756
http://dx.doi.org/10.1038/srep06659
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author Kim, Youngchan
Shim, Hyoeun
Kim, Kyoohyun
Park, HyunJoo
Jang, Seongsoo
Park, YongKeun
author_facet Kim, Youngchan
Shim, Hyoeun
Kim, Kyoohyun
Park, HyunJoo
Jang, Seongsoo
Park, YongKeun
author_sort Kim, Youngchan
collection PubMed
description Due to its strong correlation with the pathophysiology of many diseases, information about human red blood cells (RBCs) has a crucial function in hematology. Therefore, measuring and understanding the morphological, chemical, and mechanical properties of individual RBCs is a key to understanding the pathophysiology of a number of diseases in hematology, as well as to opening up new possibilities for diagnosing diseases in their early stages. In this study, we present the simultaneous and quantitative measurement of the morphological, chemical, and mechanical parameters of individual RBCs employing optical holographic microtomography. In addition, it is demonstrated that the correlation analyses of these RBC parameters provide unique information for distinguishing and understanding diseases.
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spelling pubmed-42004122014-10-21 Profiling individual human red blood cells using common-path diffraction optical tomography Kim, Youngchan Shim, Hyoeun Kim, Kyoohyun Park, HyunJoo Jang, Seongsoo Park, YongKeun Sci Rep Article Due to its strong correlation with the pathophysiology of many diseases, information about human red blood cells (RBCs) has a crucial function in hematology. Therefore, measuring and understanding the morphological, chemical, and mechanical properties of individual RBCs is a key to understanding the pathophysiology of a number of diseases in hematology, as well as to opening up new possibilities for diagnosing diseases in their early stages. In this study, we present the simultaneous and quantitative measurement of the morphological, chemical, and mechanical parameters of individual RBCs employing optical holographic microtomography. In addition, it is demonstrated that the correlation analyses of these RBC parameters provide unique information for distinguishing and understanding diseases. Nature Publishing Group 2014-10-17 /pmc/articles/PMC4200412/ /pubmed/25322756 http://dx.doi.org/10.1038/srep06659 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Article
Kim, Youngchan
Shim, Hyoeun
Kim, Kyoohyun
Park, HyunJoo
Jang, Seongsoo
Park, YongKeun
Profiling individual human red blood cells using common-path diffraction optical tomography
title Profiling individual human red blood cells using common-path diffraction optical tomography
title_full Profiling individual human red blood cells using common-path diffraction optical tomography
title_fullStr Profiling individual human red blood cells using common-path diffraction optical tomography
title_full_unstemmed Profiling individual human red blood cells using common-path diffraction optical tomography
title_short Profiling individual human red blood cells using common-path diffraction optical tomography
title_sort profiling individual human red blood cells using common-path diffraction optical tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200412/
https://www.ncbi.nlm.nih.gov/pubmed/25322756
http://dx.doi.org/10.1038/srep06659
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