Zebrafish as a model to study live mucus physiology

Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selec...

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Autores principales: Jevtov, Irena, Samuelsson, Tore, Yao, Grace, Amsterdam, Adam, Ribbeck, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200417/
https://www.ncbi.nlm.nih.gov/pubmed/25323747
http://dx.doi.org/10.1038/srep06653
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author Jevtov, Irena
Samuelsson, Tore
Yao, Grace
Amsterdam, Adam
Ribbeck, Katharina
author_facet Jevtov, Irena
Samuelsson, Tore
Yao, Grace
Amsterdam, Adam
Ribbeck, Katharina
author_sort Jevtov, Irena
collection PubMed
description Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology.
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spelling pubmed-42004172014-10-21 Zebrafish as a model to study live mucus physiology Jevtov, Irena Samuelsson, Tore Yao, Grace Amsterdam, Adam Ribbeck, Katharina Sci Rep Article Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues in zebrafish, and demonstrated a strategy for fluorescence labeling of one selected mucin. These tools can be used for in vivo experiments and in pharmacological and genetic screens to study the dynamics and mechanisms of mucosal physiology. Nature Publishing Group 2014-10-17 /pmc/articles/PMC4200417/ /pubmed/25323747 http://dx.doi.org/10.1038/srep06653 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Jevtov, Irena
Samuelsson, Tore
Yao, Grace
Amsterdam, Adam
Ribbeck, Katharina
Zebrafish as a model to study live mucus physiology
title Zebrafish as a model to study live mucus physiology
title_full Zebrafish as a model to study live mucus physiology
title_fullStr Zebrafish as a model to study live mucus physiology
title_full_unstemmed Zebrafish as a model to study live mucus physiology
title_short Zebrafish as a model to study live mucus physiology
title_sort zebrafish as a model to study live mucus physiology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200417/
https://www.ncbi.nlm.nih.gov/pubmed/25323747
http://dx.doi.org/10.1038/srep06653
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AT amsterdamadam zebrafishasamodeltostudylivemucusphysiology
AT ribbeckkatharina zebrafishasamodeltostudylivemucusphysiology

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