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Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆

Previous studies showed that tyrosine hydroxylase or neurturin gene-modified cells transplanted into rats with Parkinson’s disease significantly improved behavior and increased striatal dopamine content. In the present study, we transplanted tyrosine hydroxylase and neurturin gene-modified bone marr...

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Autores principales: Huang, Yue, Chang, Cheng, Zhang, Jiewen, Gao, Xiaoqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200733/
https://www.ncbi.nlm.nih.gov/pubmed/25337111
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.34.002
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author Huang, Yue
Chang, Cheng
Zhang, Jiewen
Gao, Xiaoqun
author_facet Huang, Yue
Chang, Cheng
Zhang, Jiewen
Gao, Xiaoqun
author_sort Huang, Yue
collection PubMed
description Previous studies showed that tyrosine hydroxylase or neurturin gene-modified cells transplanted into rats with Parkinson’s disease significantly improved behavior and increased striatal dopamine content. In the present study, we transplanted tyrosine hydroxylase and neurturin gene-modified bone marrow-derived mesenchymal stem cells into the damaged striatum of Parkinson’s disease model rats. Several weeks after cell transplantation, in addition to an improvement of motor function, tyrosine hydroxylase and neurturin proteins were up-regulated in the injured striatum, and importantly, levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid increased significantly. Furthermore, the density of the D2 dopamine receptor in the postsynaptic membranes of dopaminergic neurons was decreased. These results indicate that transplantation of tyrosine hydroxylase and neurturin gene-modified bone marrow-derived mesenchymal stem cells increases dopamine synthesis and significantly improves the behavior of rats with Parkinson’s disease.
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spelling pubmed-42007332014-10-21 Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆ Huang, Yue Chang, Cheng Zhang, Jiewen Gao, Xiaoqun Neural Regen Res Stem Cells and Neural Regeneration Previous studies showed that tyrosine hydroxylase or neurturin gene-modified cells transplanted into rats with Parkinson’s disease significantly improved behavior and increased striatal dopamine content. In the present study, we transplanted tyrosine hydroxylase and neurturin gene-modified bone marrow-derived mesenchymal stem cells into the damaged striatum of Parkinson’s disease model rats. Several weeks after cell transplantation, in addition to an improvement of motor function, tyrosine hydroxylase and neurturin proteins were up-regulated in the injured striatum, and importantly, levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid increased significantly. Furthermore, the density of the D2 dopamine receptor in the postsynaptic membranes of dopaminergic neurons was decreased. These results indicate that transplantation of tyrosine hydroxylase and neurturin gene-modified bone marrow-derived mesenchymal stem cells increases dopamine synthesis and significantly improves the behavior of rats with Parkinson’s disease. Medknow Publications & Media Pvt Ltd 2012-12-05 /pmc/articles/PMC4200733/ /pubmed/25337111 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.34.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Stem Cells and Neural Regeneration
Huang, Yue
Chang, Cheng
Zhang, Jiewen
Gao, Xiaoqun
Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
title Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
title_full Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
title_fullStr Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
title_full_unstemmed Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
title_short Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
title_sort bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum☆
topic Stem Cells and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200733/
https://www.ncbi.nlm.nih.gov/pubmed/25337111
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.34.002
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AT gaoxiaoqun bonemarrowderivedmesenchymalstemcellsincreasedopaminesynthesisintheinjuredstriatum