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Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression

OCT4 (octamer-binding transcription factor) is a transcription factor responsible for maintaining the pluripotent properties of embryonic stem cells. In this paper, we present the results of studies to investigate the role of the OCT4 splicing variant in urothelial bladder cancer and the relationshi...

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Autores principales: Jóźwicki, Wojciech, Brożyna, Anna A., Siekiera, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200762/
https://www.ncbi.nlm.nih.gov/pubmed/25216339
http://dx.doi.org/10.3390/ijms150916069
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author Jóźwicki, Wojciech
Brożyna, Anna A.
Siekiera, Jerzy
author_facet Jóźwicki, Wojciech
Brożyna, Anna A.
Siekiera, Jerzy
author_sort Jóźwicki, Wojciech
collection PubMed
description OCT4 (octamer-binding transcription factor) is a transcription factor responsible for maintaining the pluripotent properties of embryonic stem cells. In this paper, we present the results of studies to investigate the role of the OCT4 splicing variant in urothelial bladder cancer and the relationship between the OCT4 phenotype and the morphological parameters of tumor malignancy. Ninety patients who received a cystectomy for bladder cancer were enrolled. The expression of OCT4 protein was analyzed by immunohistochemistry. The ratio of OCT4-positive cells was the lowest in pT1 (pathological assessment (p)—tumor extent confined to mucosa (T1)) tumors and the highest in pTis (non-papillary tumor extent confined to urothelium) and pT2 (tumor extent including muscularis propria) tumors. Information about the percentage of OCT4A-positive tumor cells could facilitate choosing the treatment mode in borderline pTis–pT1 (crossing the border of the basement membrane; the first stage of progression) and pT1–pT2 (crossing the border of the muscularis propria; the second stage of progression) cases: a higher percentage of OCT4A-positive cells should support more radical therapy. A significantly higher percentage of cases with moderate OCT4 intensity was found in metastasizing (the third stage of progression) cases with >2 positive lymph nodes. The percentage of OCT4-positive cells was significantly higher for cancers with a high grade, higher non-classic differentiation number and greater aggressiveness of invasion. The differentiation, maturation and aggressiveness of tumor invasion appear to depend on the expression of the OCT4 phenotype in cancer cells, similar to the successive stages of malignancy progression in urothelial cancer.
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spelling pubmed-42007622014-10-17 Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression Jóźwicki, Wojciech Brożyna, Anna A. Siekiera, Jerzy Int J Mol Sci Article OCT4 (octamer-binding transcription factor) is a transcription factor responsible for maintaining the pluripotent properties of embryonic stem cells. In this paper, we present the results of studies to investigate the role of the OCT4 splicing variant in urothelial bladder cancer and the relationship between the OCT4 phenotype and the morphological parameters of tumor malignancy. Ninety patients who received a cystectomy for bladder cancer were enrolled. The expression of OCT4 protein was analyzed by immunohistochemistry. The ratio of OCT4-positive cells was the lowest in pT1 (pathological assessment (p)—tumor extent confined to mucosa (T1)) tumors and the highest in pTis (non-papillary tumor extent confined to urothelium) and pT2 (tumor extent including muscularis propria) tumors. Information about the percentage of OCT4A-positive tumor cells could facilitate choosing the treatment mode in borderline pTis–pT1 (crossing the border of the basement membrane; the first stage of progression) and pT1–pT2 (crossing the border of the muscularis propria; the second stage of progression) cases: a higher percentage of OCT4A-positive cells should support more radical therapy. A significantly higher percentage of cases with moderate OCT4 intensity was found in metastasizing (the third stage of progression) cases with >2 positive lymph nodes. The percentage of OCT4-positive cells was significantly higher for cancers with a high grade, higher non-classic differentiation number and greater aggressiveness of invasion. The differentiation, maturation and aggressiveness of tumor invasion appear to depend on the expression of the OCT4 phenotype in cancer cells, similar to the successive stages of malignancy progression in urothelial cancer. MDPI 2014-09-11 /pmc/articles/PMC4200762/ /pubmed/25216339 http://dx.doi.org/10.3390/ijms150916069 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jóźwicki, Wojciech
Brożyna, Anna A.
Siekiera, Jerzy
Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression
title Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression
title_full Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression
title_fullStr Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression
title_full_unstemmed Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression
title_short Expression of OCT4A: The First Step to the Next Stage of Urothelial Bladder Cancer Progression
title_sort expression of oct4a: the first step to the next stage of urothelial bladder cancer progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200762/
https://www.ncbi.nlm.nih.gov/pubmed/25216339
http://dx.doi.org/10.3390/ijms150916069
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