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Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insu...

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Autores principales: Jenwitheesuk, Anorut, Nopparat, Chutikorn, Mukda, Sujira, Wongchitrat, Prapimpun, Govitrapong, Piyarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200827/
https://www.ncbi.nlm.nih.gov/pubmed/25247581
http://dx.doi.org/10.3390/ijms150916848
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author Jenwitheesuk, Anorut
Nopparat, Chutikorn
Mukda, Sujira
Wongchitrat, Prapimpun
Govitrapong, Piyarat
author_facet Jenwitheesuk, Anorut
Nopparat, Chutikorn
Mukda, Sujira
Wongchitrat, Prapimpun
Govitrapong, Piyarat
author_sort Jenwitheesuk, Anorut
collection PubMed
description Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.
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spelling pubmed-42008272014-10-17 Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways Jenwitheesuk, Anorut Nopparat, Chutikorn Mukda, Sujira Wongchitrat, Prapimpun Govitrapong, Piyarat Int J Mol Sci Review Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions. MDPI 2014-09-22 /pmc/articles/PMC4200827/ /pubmed/25247581 http://dx.doi.org/10.3390/ijms150916848 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Jenwitheesuk, Anorut
Nopparat, Chutikorn
Mukda, Sujira
Wongchitrat, Prapimpun
Govitrapong, Piyarat
Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_full Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_fullStr Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_full_unstemmed Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_short Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
title_sort melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200827/
https://www.ncbi.nlm.nih.gov/pubmed/25247581
http://dx.doi.org/10.3390/ijms150916848
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