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Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Eluc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200833/ https://www.ncbi.nlm.nih.gov/pubmed/25257534 http://dx.doi.org/10.3390/ijms150917162 |
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author | Visone, Valeria Vettone, Antonella Serpe, Mario Valenti, Anna Perugino, Giuseppe Rossi, Mosè Ciaramella, Maria |
author_facet | Visone, Valeria Vettone, Antonella Serpe, Mario Valenti, Anna Perugino, Giuseppe Rossi, Mosè Ciaramella, Maria |
author_sort | Visone, Valeria |
collection | PubMed |
description | In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Elucidation of chromatin composition and regulation is a critical issue in biology, because of the intimate connection of chromatin with all the essential information processes (transcription, replication, recombination, and repair). Chromatin proteins include architectural proteins and DNA topoisomerases, which regulate genome structure and remodelling at two hierarchical levels. This review is focussed on architectural proteins and topoisomerases from hyperthermophilic Archaea. In these organisms, which live at high environmental temperature (>80 °C <113 °C), chromatin proteins and modulation of the DNA secondary structure are concerned with the problem of DNA stabilization against heat denaturation while maintaining its metabolic activity. |
format | Online Article Text |
id | pubmed-4200833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42008332014-10-17 Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea Visone, Valeria Vettone, Antonella Serpe, Mario Valenti, Anna Perugino, Giuseppe Rossi, Mosè Ciaramella, Maria Int J Mol Sci Review In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Elucidation of chromatin composition and regulation is a critical issue in biology, because of the intimate connection of chromatin with all the essential information processes (transcription, replication, recombination, and repair). Chromatin proteins include architectural proteins and DNA topoisomerases, which regulate genome structure and remodelling at two hierarchical levels. This review is focussed on architectural proteins and topoisomerases from hyperthermophilic Archaea. In these organisms, which live at high environmental temperature (>80 °C <113 °C), chromatin proteins and modulation of the DNA secondary structure are concerned with the problem of DNA stabilization against heat denaturation while maintaining its metabolic activity. MDPI 2014-09-25 /pmc/articles/PMC4200833/ /pubmed/25257534 http://dx.doi.org/10.3390/ijms150917162 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Visone, Valeria Vettone, Antonella Serpe, Mario Valenti, Anna Perugino, Giuseppe Rossi, Mosè Ciaramella, Maria Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea |
title | Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea |
title_full | Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea |
title_fullStr | Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea |
title_full_unstemmed | Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea |
title_short | Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea |
title_sort | chromatin structure and dynamics in hot environments: architectural proteins and dna topoisomerases of thermophilic archaea |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200833/ https://www.ncbi.nlm.nih.gov/pubmed/25257534 http://dx.doi.org/10.3390/ijms150917162 |
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