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Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea

In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Eluc...

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Autores principales: Visone, Valeria, Vettone, Antonella, Serpe, Mario, Valenti, Anna, Perugino, Giuseppe, Rossi, Mosè, Ciaramella, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200833/
https://www.ncbi.nlm.nih.gov/pubmed/25257534
http://dx.doi.org/10.3390/ijms150917162
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author Visone, Valeria
Vettone, Antonella
Serpe, Mario
Valenti, Anna
Perugino, Giuseppe
Rossi, Mosè
Ciaramella, Maria
author_facet Visone, Valeria
Vettone, Antonella
Serpe, Mario
Valenti, Anna
Perugino, Giuseppe
Rossi, Mosè
Ciaramella, Maria
author_sort Visone, Valeria
collection PubMed
description In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Elucidation of chromatin composition and regulation is a critical issue in biology, because of the intimate connection of chromatin with all the essential information processes (transcription, replication, recombination, and repair). Chromatin proteins include architectural proteins and DNA topoisomerases, which regulate genome structure and remodelling at two hierarchical levels. This review is focussed on architectural proteins and topoisomerases from hyperthermophilic Archaea. In these organisms, which live at high environmental temperature (>80 °C <113 °C), chromatin proteins and modulation of the DNA secondary structure are concerned with the problem of DNA stabilization against heat denaturation while maintaining its metabolic activity.
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spelling pubmed-42008332014-10-17 Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea Visone, Valeria Vettone, Antonella Serpe, Mario Valenti, Anna Perugino, Giuseppe Rossi, Mosè Ciaramella, Maria Int J Mol Sci Review In all organisms of the three living domains (Bacteria, Archaea, Eucarya) chromosome-associated proteins play a key role in genome functional organization. They not only compact and shape the genome structure, but also regulate its dynamics, which is essential to allow complex genome functions. Elucidation of chromatin composition and regulation is a critical issue in biology, because of the intimate connection of chromatin with all the essential information processes (transcription, replication, recombination, and repair). Chromatin proteins include architectural proteins and DNA topoisomerases, which regulate genome structure and remodelling at two hierarchical levels. This review is focussed on architectural proteins and topoisomerases from hyperthermophilic Archaea. In these organisms, which live at high environmental temperature (>80 °C <113 °C), chromatin proteins and modulation of the DNA secondary structure are concerned with the problem of DNA stabilization against heat denaturation while maintaining its metabolic activity. MDPI 2014-09-25 /pmc/articles/PMC4200833/ /pubmed/25257534 http://dx.doi.org/10.3390/ijms150917162 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Visone, Valeria
Vettone, Antonella
Serpe, Mario
Valenti, Anna
Perugino, Giuseppe
Rossi, Mosè
Ciaramella, Maria
Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
title Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
title_full Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
title_fullStr Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
title_full_unstemmed Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
title_short Chromatin Structure and Dynamics in Hot Environments: Architectural Proteins and DNA Topoisomerases of Thermophilic Archaea
title_sort chromatin structure and dynamics in hot environments: architectural proteins and dna topoisomerases of thermophilic archaea
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200833/
https://www.ncbi.nlm.nih.gov/pubmed/25257534
http://dx.doi.org/10.3390/ijms150917162
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